Biomed Engineering Science Division

Research output

Research output per year 1982 2000 2001 2003 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2021 2024

• 663 Article
• 52 Conference contribution
• 29 Review article
• 26 Conference article
• 76 More
  • 25 Other contribution
  • 20 Chapter
  • 10 Poster
  • 7 Comment/debate
  • 4 Preprint
  • 2 Paper
  • 2 Doctoral Thesis
  • 1 Book
  • 1 Foreword/postscript
  • 1 Editorial
  • 1 Letter
  • 1 Short survey
  • 1 Digital or Visual Products

Research output per year

Research output per year

Search results

• 2024

  A prototype scintillator real-time beam monitor for ultra-high dose rate radiotherapy

  Levin, D. S., Friedman, P. S., Ferretti, C., Ristow, N., Tecchio, M., Litzenberg, D. W., Bashkirov, V. & Schulte, R., Apr 2024, In: Medical Physics. 51, 4, p. 2905-2923 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2023

  A likelihood-based particle imaging filter using prior information

  Fullarton, R., Volz, L., Dikaios, N., Schulte, R., Royle, G., Evans, P. M., Seco, J. & Collins-Fekete, C. A., Apr 2023, In: Medical Physics. 50, 4, p. 2336-2353 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Effects of acute low-moderate dose ionizing radiation to human brain organoids

  Oyefeso, F. A., Goldberg, G., Opoku, N. Y. P. S., Vazquez, M., Bertucci, A., Chen, Z., Wang, C., Muotri, A. R. & Pecaut, M. J., May 2023, In: PLoS ONE. 18, 5 May, e0282958.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Evidence of Spaceflight-Induced Adverse Effects on Photoreceptors and Retinal Function in the Mouse Eye

  Mao, X., Stanbouly, S., Holley, J., Pecaut, M. & Crapo, J., Apr 2023, In: International Journal of Molecular Sciences. 24, 8, 7362.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Spaceflight-Induced Gene Expression Profiles in the Mouse Brain Are Attenuated by Treatment with the Antioxidant BuOE

  Kremsky, I., Ali, S., Stanbouly, S., Holley, J., Justinen, S., Pecaut, M., Crapo, J. & Mao, X., Sep 2023, In: International Journal of Molecular Sciences. 24, 17, 13569.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Transcriptomic Effects on the Mouse Heart Following 30 Days on the International Space Station

  Veliz, A. L., Mamoun, L., Hughes, L., Vega, R., Holmes, B., Monteon, A., Bray, J., Pecaut, M. J. & Kearns-Jonker, M., Feb 2023, In: Biomolecules. 13, 2, 371.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2022

  A dose–volume constraint (DVC) projection-based algorithm for IMPT inverse planning optimization

  Gadoue, S. M., Toomeh, D., Schultze, B. E. & Schulte, R. W., Apr 2022, In: Medical Physics. 49, 4, p. 2699-2708 10 p.

  Research output: Contribution to journal › Article › peer-review

• Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission

  Holley, J. M., Stanbouly, S., Pecaut, M. J., Willey, J. S., Delp, M. & Mao, X. W., Dec 2022, In: npj Microgravity. 8, 1, 35.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Comparative accuracy and resolution assessment of two prototype proton computed tomography scanners

  Dedes, G., Drosten, H., Götz, S., Dickmann, J., Sarosiek, C., Pankuch, M., Krah, N., Rit, S., Bashkirov, V., Schulte, R. W., Johnson, R. P., Parodi, K., DeJongh, E. & Landry, G., Jul 2022, In: Medical Physics. 49, 7, p. 4671-4681 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Developments in Mathematical Algorithms and Computational Tools for Proton CT and Particle Therapy Treatment Planning

  Censor, Y., Schubert, K. E. & Schulte, R. W., Mar 1 2022, In: IEEE Transactions on Radiation and Plasma Medical Sciences. 6, 3, p. 313-324 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Evaluation of the impact of a scanner prototype on proton CT and helium CT image quality and dose efficiency with Monte Carlo simulation

  Götz, S., Dickmann, J., Rit, S., Krah, N., Khellaf, F., Schulte, R. W., Parodi, K., Dedes, G. & Landry, G., Mar 7 2022, In: Physics in Medicine and Biology. 67, 5, 055003.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Experimental comparison of photon versus particle computed tomography to predict tissue relative stopping powers

  Bär, E., Volz, L., Collins-Fekete, C. A., Brons, S., Runz, A., Schulte, R. W. & Seco, J., Jan 2022, In: Medical Physics. 49, 1, p. 474-487 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Imaging subtle leaks in the blood–brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions

  Montagne, A., Barnes, S. R., Nation, D. A., Kisler, K., Toga, A. W. & Zlokovic, B. V., Jun 2022, In: GeroScience. 44, 3, p. 1339-1351 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Quantitative susceptibility mapping as a measure of cerebral oxygenation in neonatal piglets

  Bartnik-Olson, B. L., Blood, A. B., Terry, M. H., Hanson, S. F. L., Day, C., Kido, D. & Kim, P., May 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 5, p. 891-900 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Repair Kinetics of DSB-Foci Induced by Proton and α-Particle Microbeams of Different Energies

  Belchior, A., Canhoto, J. F., Giesen, U., Langner, F., Rabus, H. & Schulte, R., Dec 2022, In: Life. 12, 12, 2040.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading

  Willey, J. S., Aunon-Chancellor, S., Miles, L. A., Moore, J. E., Mao, X. W., Wallace, R. W. & Foy, M. C., Dec 2022, In: npj Microgravity. 8, 1, 18.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2021

  A comparison of proton stopping power measured with proton CT and x-ray CT in fresh postmortem porcine structures

  DeJongh, D. F., DeJongh, E. A., Rykalin, V., DeFillippo, G., Pankuch, M., Best, A. W., Coutrakon, G., Duffin, K. L., Karonis, N. T., Ordoñez, C. E., Sarosiek, C., Schulte, R. W., Winans, J. R., Block, A. M., Hentz, C. L. & Welsh, J. S., Dec 2021, In: Medical Physics. 48, 12, p. 7998-8009 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• An Analysis of the Effects of Spaceflight and Vaccination on Antibody Repertoire Diversity

  Rettig, T. A., Tan, J. C., Nishiyama, N. C., Chapes, S. K. & Pecaut, M. J., Aug 1 2021, In: ImmunoHorizons. 5, 8, p. 675-686 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• An empirical artifact correction for proton computed tomography

  Dickmann, J., Sarosiek, C., Götz, S., Pankuch, M., Coutrakon, G., Johnson, R. P., Schulte, R. W., Parodi, K., Landry, G. & Dedes, G., Jun 2021, In: Physica Medica. 86, p. 57-65 9 p.

  Research output: Contribution to journal › Article › peer-review

• APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-β

  Montagne, A., Nikolakopoulou, A. M., Huuskonen, M. T., Sagare, A. P., Lawson, E. J., Lazic, D., Rege, S. V., Grond, A., Zuniga, E., Barnes, S. R., Prince, J., Sagare, M., Hsu, C. J., LaDu, M. J., Jacobs, R. E. & Zlokovic, B. V., Jun 2021, In: Nature Aging. 1, 6, p. 506-520 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group

  Dennis, E. L., Caeyenberghs, K., Asarnow, R. F., Babikian, T., Bartnik-Olson, B., Bigler, E. D., Figaji, A., Giza, C. C., Goodrich-Hunsaker, N. J., Hodges, C. B., Hoskinson, K. R., Königs, M., Levin, H. S., Lindsey, H. M., Livny, A., Max, J. E., Merkley, T. L., Newsome, M. R., Olsen, A., Ryan, N. P., & 11 othersSpruiell, M. S., Suskauer, S. J., Thomopoulos, S. I., Ware, A. L., Watson, C. G., Wheeler, A. L., Yeates, K. O., Zielinski, B. A., Thompson, P. M., Tate, D. F. & Wilde, E. A., Apr 2021, In: Brain Imaging and Behavior. 15, 2, p. 555-575 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Evaluating ocular response in the retina and optic nerve head after single and fractionated high-energy protons

  Mao, X. W., Stanbouly, S., Jones, T. & Nelson, G., Aug 2021, In: Life. 11, 8, 849.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Evolving White Matter Injury following Pediatric Traumatic Brain Injury

  Bartnik-Olson, B., Holshouser, B., Ghosh, N., Oyoyo, U. E., Nichols, J. G., Pivonka-Jones, J., Tong, K. & Ashwal, S., Jan 1 2021, In: Journal of Neurotrauma. 38, 1, p. 111-121 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Fluence-modulated proton CT optimized with patient-specific dose and variance objectives for proton dose calculation

  Dickmann, J., Kamp, F., Hillbrand, M., Corradini, S., Belka, C., Schulte, R. W., Parodi, K., Dedes, G. & Landry, G., Mar 21 2021, In: Physics in Medicine and Biology. 66, 6, 064001.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity

  Paul, A. M., Overbey, E. G., da Silveira, W. A., Szewczyk, N., Nishiyama, N. C., Pecaut, M. J., Anand, S., Galazka, J. M. & Mao, X. W., Dec 2021, In: Scientific Reports. 11, 1, 11452.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Omega-3 fatty acids are associated with blood–brain barrier integrity in a healthy aging population

  Barnes, S., Chowdhury, S., Gatto, N. M., Fraser, G. E. & Lee, G. J., Aug 2021, In: Brain and Behavior. 11, 8, e2273.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Particle-Tracking Proton Computed Tomography-Data Acquisition, Preprocessing, and Preconditioning

  Schultze, B., Karbasi, P., Sarosiek, C., Coutrakon, G., Ordonez, C. E., Karonis, N. T., Duffin, K. L., Bashkirov, V. A., Johnson, R. P., Schubert, K. E. & Schulte, R. W., 2021, In: IEEE Access. 9, p. 25946-25958 13 p., 9349505.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Proof of concept image artifact reduction by energy-modulated proton computed tomography (EMpCT)

  Dickmann, J., Sarosiek, C., Rykalin, V., Pankuch, M., Coutrakon, G., Johnson, R. P., Bashkirov, V., Schulte, R. W., Parodi, K., Landry, G. & Dedes, G., Jan 2021, In: Physica Medica. 81, p. 237-244 8 p.

  Research output: Contribution to journal › Article › peer-review

• Societal return on investment may greatly exceed financial return on investment in neurotechnology-based therapies: A case study in epilepsy therapy development

  DiLorenzo, D. J., Apr 19 2021, In: Surgical Neurology International. 12, 180.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents

  Kwok, A. T., Mohamed, N. S., Plate, J. F., Yammani, R. R., Rosas, S., Bateman, T. A., Livingston, E., Moore, J. E., Kerr, B. A., Lee, J., Furdui, C. M., Tan, L., Bouxsein, M. L., Ferguson, V. L., Stodieck, L. S., Zawieja, D. C., Delp, M. D., Mao, X. W. & Willey, J. S., Dec 2021, In: Scientific Reports. 11, 1, 10469.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina

  Chen, Z., Stanbouly, S., Nishiyama, N. C., Chen, X., Delp, M. D., Qiu, H., Mao, X. W. & Wang, C., Jun 1 2021, In: Precision Clinical Medicine. 4, 2, p. 93-108 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The accuracy of helium ion CT based particle therapy range prediction: an experimental study comparing different particle and x-ray CT modalities

  Volz, L., Collins-Fekete, C. A., B r, E., Brons, S., Graeff, C., Johnson, R. P., Runz, A., Sarosiek, C., Schulte, R. W. & Seco, J., Dec 7 2021, In: Physics in Medicine and Biology. 66, 23, 235010.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The clinical utility of proton magnetic resonance spectroscopy in traumatic brain injury: recommendations from the ENIGMA MRS working group

  Bartnik-Olson, B. L., Alger, J. R., Babikian, T., Harris, A. D., Holshouser, B., Kirov, I. I., Maudsley, A. A., Thompson, P. M., Dennis, E. L., Tate, D. F., Wilde, E. A. & Lin, A., Apr 2021, In: Brain Imaging and Behavior. 15, 2, p. 504-525 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures

  Krukowski, K., Grue, K., Becker, M., Elizarraras, E., Frias, E. S., Halvorsen, A., Koenig-Zanoff, M., Frattini, V., Nimmagadda, H., Feng, X., Jones, T., Nelson, G., Ferguson, A. R. & Rosi, S., Oct 2021, In: Science Advances. 7, 42, eabg6702.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes

  Willey, J. S., Britten, R. A., Blaber, E., Tahimic, C. G. T., Chancellor, J., Mortreux, M., Sanford, L. D., Kubik, A. J., Delp, M. D. & Mao, X. W., 2021, In: Journal of Environmental Science and Health, Part C: Toxicology and Carcinogenesis. 39, 2, p. 129-179 51 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• White Matter Disruption in Pediatric Traumatic Brain Injury: Results From ENIGMA Pediatric Moderate to Severe Traumatic Brain Injury

  Dennis, E. L., Caeyenberghs, K., Hoskinson, K. R., Merkley, T. L., Suskauer, S. J., Asarnow, R. F., Babikian, T., Bartnik-Olson, B., Bickart, K., Bigler, E. D., Ewing-Cobbs, L., Figaji, A., Giza, C. C., Goodrich-Hunsaker, N. J., Hodges, C. B., Hovenden, E. S., Irimia, A., Königs, M., Levin, H. S., Lindsey, H. M., & 17 othersMax, J. E., Newsome, M. R., Olsen, A., Ryan, N. P., Schmidt, A. T., Spruiell, M. S., Wade, B. S. C., Ware, A. L., Watson, C. G., Wheeler, A. L., Yeates, K. O., Zielinski, B. A., Kochunov, P., Jahanshad, N., Thompson, P. M., Tate, D. F. & Wilde, E. A., Jul 20 2021, In: Neurology. 97, 3, p. E298-E309

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2020

  Altered Cognitive Flexibility and Synaptic Plasticity in the Rat Prefrontal Cortex after Exposure to Low (≤15 cGy) Doses of ²⁸Si Radiation

  Britten, R. A., Duncan, V. D., Fesshaye, A., Rudobeck, E., Nelson, G. A. & Vlkolinsky, R., Mar 2020, In: Radiation Research. 193, 3, p. 223-235 13 p.

  Research output: Contribution to journal › Article › peer-review

• Altered rodent gait characteristics after ~35 days in orbit aboard the International Space Station

  Kwok, A., Rosas, S., Bateman, T. A., Livingston, E., Smith, T. L., Moore, J., Zawieja, D. C., Hampton, T., Mao, X. W., Delp, M. D. & Willey, J. S., Feb 2020, In: Life Sciences in Space Research. 24, p. 9-17 9 p.

  Research output: Contribution to journal › Article › peer-review

• An Improved Method of Total Variation Superiorization Applied to Reconstruction in Proton Computed Tomography

  Schultze, B., Censor, Y., Karbasi, P., Schubert, K. E. & Schulte, R. W., Feb 2020, In: IEEE Transactions on Medical Imaging. 39, 2, p. 294-307 14 p., 8692608.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• An optimization algorithm for dose reduction with fluence-modulated proton CT

  Dickmann, J., Rit, S., Pankuch, M., Johnson, R. P., Schulte, R. W., Parodi, K., Dedes, G. & Landry, G., Apr 1 2020, In: Medical Physics. 47, 4, p. 1895-1906 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Assessment of global ocular structure following spaceflight using a micro-computed tomography (Micro-ct) imaging method

  Roque-Torres, G. D., Nishiyama, N. C., Stanbouly, S. & Mao, X. W., Oct 2020, In: Journal of Visualized Experiments. 2020, 164, e61227.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Cosyntropin Attenuates Neuroinflammation in a Mouse Model of Traumatic Brain Injury

  Siebold, L., Krueger, A. C., Abdala, J. A., Figueroa, J. D., Bartnik-Olson, B., Holshouser, B., Wilson, C. G. & Ashwal, S., Jun 26 2020, In: Frontiers in Molecular Neuroscience. 13, 109.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats

  Sridharan, V., Seawright, J. W., Landes, R. D., Cao, M., Singh, P., Davis, C. M., Mao, X. W., Singh, S. P., Zhang, X., Nelson, G. A. & Boerma, M., Aug 2020, In: Life Sciences in Space Research. 26, p. 62-68 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Experimental realization of dynamic fluence field optimization for proton computed tomography

  Dickmann, J., Sarosiek, C., Rykalin, V., Pankuch, M., Rit, S., Detrich, N., Coutrakon, G., Johnson, R. P., Schulte, R. W., Parodi, K., Landry, G. & Dedes, G., Oct 7 2020, In: Physics in Medicine and Biology. 65, 19, 195001.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Multiple sensory illusions are evoked during the course of proton therapy

  Narici, L., Titova, E., Obenaus, A., Wroe, A., Loredo, L., Schulte, R., Slater, J. D. & Nelson, G. A., Aug 2020, In: Life Sciences in Space Research. 26, p. 140-148 9 p.

  Research output: Contribution to journal › Article › peer-review

• Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model

  Mao, X. W., Nishiyama, N. C., Byrum, S. D., Stanbouly, S., Jones, T., Holley, J., Sridharan, V., Boerma, M., Tackett, A. J., Willey, J. S., Pecaut, M. J. & Delp, M. D., Nov 1 2020, In: FASEB Journal. 34, 11, p. 15516-15530 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2019

  Abstract # 3119 I am woman, watch me soar: females protected from cosmic ray-induced behavioral deficits, microglia activation and synaptic loss

  Krukowski, K., Grue, K., Frias, E., Pietrykowski, J., Rayasam, A., Jones, T., Nelson, G. & Rosi, S., Feb 1 2019, In: Brain Behavior and Immunity. 76

  Research output: Contribution to journal › Article › peer-review

• Accuracy of low-dose proton CT image registration for pretreatment alignment verification in reference to planning proton CT

  Cassetta, R., Piersimoni, P., Riboldi, M., Giacometti, V., Bashkirov, V., Baroni, G., Ordonez, C., Coutrakon, G. & Schulte, R., Apr 2019, In: Journal of Applied Clinical Medical Physics. 20, 4, p. 83-90 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• A comparison of unamplified and massively multiplexed PCR amplification for murine antibody repertoire sequencing

  Rettig, T. A., Pecaut, M. J. & Chapes, S. K., Jan 2019, In: FASEB BioAdvances. 1, 1, p. 6-17 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• A New Standard DNA Damage (SDD) Data Format

  Schuemann, J., Mcnamara, A. L., Warmenhoven, J. W., Henthorn, N. T., Kirkby, K. J., Merchant, M. J., Ingram, S., Paganetti, H., Held, K. D., Ramos-Mendez, J., Faddegon, B., Perl, J., Goodhead, D. T., Plante, I., Rabus, H., Nettelbeck, H., Friedland, W., Kundrát, P., Ottolenghi, A., Baiocco, G., & 35 othersBarbieri, S., Dingfelder, M., Incerti, S., Villagrasa, C., Bueno, M., Bernal, M. A., Guatelli, S., Sakata, D., Brown, J. M. C., Francis, Z., Kyriakou, I., Lampe, N., Ballarini, F., Carante, M. P., Davídková, M., Štepán, V., Jia, X., Cucinotta, F. A., Schulte, R., Stewart, R. D., Carlson, D. J., Galer, S., Kuncic, Z., Lacombe, S., Milligan, J., Cho, S. H., Sawakuchi, G., Inaniwa, T., Sato, T., Li, W., Solov'yov, A. V., Surdutovich, E., Durante, M., Prise, K. M. & Mcmahon, S. J., Jan 1 2019, In: Radiation Research. 191, 1, p. 76-92 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access