TY - JOUR
T1 - Peritoneal carcinomatosis in gastric cancer
T2 - Are Hispanics at higher risk?
AU - Choi, Audrey H.
AU - Ji, Liang
AU - Babcock, Blake
AU - Ramos, Vicente
AU - Kwong, Mei Li M.
AU - Morgan, John W.
AU - Selleck, Matthew J.
AU - Langridge, William H.R.
AU - DeLeon, Marino
AU - Wall, Nathan R.
AU - Lum, Sharon
AU - Pigazzi, Alessio
AU - Dayyani, Farshid
AU - Senthil, Maheswari
N1 - Publisher Copyright:
© 2020 Wiley Periodicals LLC
PY - 2020/12/15
Y1 - 2020/12/15
N2 - Background: A recent study from our group identified Hispanic race/ethnicity as an independent predictor of peritoneal carcinomatosis (PC) in gastric cancer. We sought to identify the tumor factors that might contribute to this strong association in Hispanics. Methods: California Cancer Registry data were used to identify patients diagnosed with gastric adenocarcinoma from 2004 to 2014. Logistic regression analyses were performed to determine odds ratios for cancer stage, tumor location, grade, histology, and PC. Results: Of 16,275 patients with gastric adenocarcinoma who met inclusion criteria, 6463 (39.7%) were non-Hispanic White (NHW), 4953 (30.4%) were Hispanic, 1020 (6.3%) were non-Hispanic Black (NHB), and 3915 (23.6%) were Asian/other. Compared to NHW, Hispanics were more likely to have a poorly differentiated grade (65.9% vs. 57.6%; p <.001), signet ring adenocarcinoma (28.1% vs. 17.6%; p <.001) and stage IV (51.9% vs. 45.0%; p <.001) gastric cancer. The proportion of stage IV patients with PC was also significantly higher in Hispanics compared to NHW, NHB, and Asian/other (28.5% vs. 16.6%, 20.5%, and 25.2%, respectively; p <.001). Conclusions: Hispanic ethnicity is an independent predictor of aggressive tumor phenotype and PC. Disproportionate incidence of signet ring adenocarcinoma and PC highlight the need to explore the genomic differences in Hispanic gastric cancer.
AB - Background: A recent study from our group identified Hispanic race/ethnicity as an independent predictor of peritoneal carcinomatosis (PC) in gastric cancer. We sought to identify the tumor factors that might contribute to this strong association in Hispanics. Methods: California Cancer Registry data were used to identify patients diagnosed with gastric adenocarcinoma from 2004 to 2014. Logistic regression analyses were performed to determine odds ratios for cancer stage, tumor location, grade, histology, and PC. Results: Of 16,275 patients with gastric adenocarcinoma who met inclusion criteria, 6463 (39.7%) were non-Hispanic White (NHW), 4953 (30.4%) were Hispanic, 1020 (6.3%) were non-Hispanic Black (NHB), and 3915 (23.6%) were Asian/other. Compared to NHW, Hispanics were more likely to have a poorly differentiated grade (65.9% vs. 57.6%; p <.001), signet ring adenocarcinoma (28.1% vs. 17.6%; p <.001) and stage IV (51.9% vs. 45.0%; p <.001) gastric cancer. The proportion of stage IV patients with PC was also significantly higher in Hispanics compared to NHW, NHB, and Asian/other (28.5% vs. 16.6%, 20.5%, and 25.2%, respectively; p <.001). Conclusions: Hispanic ethnicity is an independent predictor of aggressive tumor phenotype and PC. Disproportionate incidence of signet ring adenocarcinoma and PC highlight the need to explore the genomic differences in Hispanic gastric cancer.
KW - Hispanic
KW - epidemiology
KW - gastric cancer
KW - peritoneal carcinomatosis
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U2 - 10.1002/jso.26210
DO - 10.1002/jso.26210
M3 - Article
C2 - 32901938
SN - 0022-4790
VL - 122
SP - 1624
EP - 1629
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 8
ER -