Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis

Shaun M. Sheets; Antonette G. Robles-Price; Rachelle M.E. McKenzie; Carlos A. Casiano; Hansel M. Fletcher

doi:10.2741/2922

Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis

Shaun M. Sheets, Antonette G. Robles-Price, Rachelle M.E. McKenzie, Carlos A. Casiano, Hansel M. Fletcher

Research output: Contribution to journal › Review article › peer-review

Abstract

Porphyromonas gingivalis, a major periodontal pathogen, must acquire nutrients from host derived substrates, overcome oxidative stress and subvert the immune system. These activities can be coordinated via the gingipains which represent the most significant virulence factor produced by this organism. In the context of our contribution to this field, we will review the current understanding of gingipain biogenesis, glycosylation, and regulation, as well as discuss their role in oxidative stress resistance and apoptosis. We can postulate a model, in which gingipains may be part of the mechanism for P. gingivalis virulence.

Original language	English
Pages (from-to)	3215-3238
Number of pages	24
Journal	Frontiers in Bioscience
Volume	13
Issue number	9
DOIs	https://doi.org/10.2741/2922
State	Published - 2008

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology

Keywords

Anoikis
Apoptosis
Caspase-independent apoptosis
DNA repair
Gingipains
Glycosylation
HRgpA
Host cell survival
Integrin β1
Kgp
N-cadherin
Oxidative stress
Porphyromonas gingivalis
Review
RgpB
VE-cadherin
VimA
VimE
VimF
Virulence

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title = "Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis",

abstract = "Porphyromonas gingivalis, a major periodontal pathogen, must acquire nutrients from host derived substrates, overcome oxidative stress and subvert the immune system. These activities can be coordinated via the gingipains which represent the most significant virulence factor produced by this organism. In the context of our contribution to this field, we will review the current understanding of gingipain biogenesis, glycosylation, and regulation, as well as discuss their role in oxidative stress resistance and apoptosis. We can postulate a model, in which gingipains may be part of the mechanism for P. gingivalis virulence.",

keywords = "Anoikis, Apoptosis, Caspase-independent apoptosis, DNA repair, Gingipains, Glycosylation, HRgpA, Host cell survival, Integrin β1, Kgp, N-cadherin, Oxidative stress, Porphyromonas gingivalis, Review, RgpB, VE-cadherin, VimA, VimE, VimF, Virulence",

author = "Sheets, {Shaun M.} and Robles-Price, {Antonette G.} and McKenzie, {Rachelle M.E.} and Casiano, {Carlos A.} and Fletcher, {Hansel M.}",

note = "5.2.1.1. Caspase-dependent P. gingivalis-induced apoptosis Because of the close proximity between oral pathogens and host cells in the gingiva, the interplay of P. gingivalis and the various cell types present in the gingival crevice has been under intense scrutiny.",

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AU - Robles-Price, Antonette G.

AU - McKenzie, Rachelle M.E.

AU - Casiano, Carlos A.

AU - Fletcher, Hansel M.

N1 - 5.2.1.1. Caspase-dependent P. gingivalis-induced apoptosis Because of the close proximity between oral pathogens and host cells in the gingiva, the interplay of P. gingivalis and the various cell types present in the gingival crevice has been under intense scrutiny.

PY - 2008

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N2 - Porphyromonas gingivalis, a major periodontal pathogen, must acquire nutrients from host derived substrates, overcome oxidative stress and subvert the immune system. These activities can be coordinated via the gingipains which represent the most significant virulence factor produced by this organism. In the context of our contribution to this field, we will review the current understanding of gingipain biogenesis, glycosylation, and regulation, as well as discuss their role in oxidative stress resistance and apoptosis. We can postulate a model, in which gingipains may be part of the mechanism for P. gingivalis virulence.

AB - Porphyromonas gingivalis, a major periodontal pathogen, must acquire nutrients from host derived substrates, overcome oxidative stress and subvert the immune system. These activities can be coordinated via the gingipains which represent the most significant virulence factor produced by this organism. In the context of our contribution to this field, we will review the current understanding of gingipain biogenesis, glycosylation, and regulation, as well as discuss their role in oxidative stress resistance and apoptosis. We can postulate a model, in which gingipains may be part of the mechanism for P. gingivalis virulence.

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KW - Apoptosis

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KW - DNA repair

KW - Gingipains

KW - Glycosylation

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KW - Host cell survival

KW - Integrin β1

KW - Kgp

KW - N-cadherin

KW - Oxidative stress

KW - Porphyromonas gingivalis

KW - Review

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KW - VE-cadherin

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KW - VimE

KW - VimF

KW - Virulence

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JF - Frontiers in Bioscience

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Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis

Abstract

ASJC Scopus Subject Areas

Keywords

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