Research output per year
Research output per year
Personal profile
About
Dr. Fletcher is an established investigator on microbial pathogenesis and host-microbe interaction. His pioneering work on genetic tool development for Porphyromonas lead to the first demonstration of the role of proteases in the virulence of P. gingivalis. Furthermore the genetic tool (an ermF/ermAM antibiotic resistance cassette) is the most widely used in genetics studies in P. gingivalis. His research program has provided evidence for posttranslational regulation of proteolytic activity in P. gingivalis and the first report of the identification of a gingipain proenzyme from this organism. He has also provided evidence of a new paradigm for DNA repair of 8-oxo-7,8-dihydroguanine lesions in P. gingivalis in addition to the first demonstration that gingipains from P. gingivalis can induce caspase-independent apoptosis in endothelial cells. His work with the P. gingivalis vimA (virulence modulation A) gene, identified in his laboratory, is emerging as a founding member of novel post-translational control mechanism in Gram-negatives. Dr. Fletcher has begun other studies with Fillifactor alocis, a new emerging Gram-positive bacterium that is now proposed to be a diagnostic indicator of periodontal disease. He was the first to report on the virulence potential of this organism. Dr. Fletcher’s research efforts have been supported by the National Institutes of Health (NIH), National Medical Technology Testbed, University of California Tobacco-Related Disease Research Program and other agencies or biotechnology companies.
Related documents
Education/Academic qualification
PhD, Temple University
… → 1990
Disciplines
- Educational Administration and Supervision
- Laboratory and Basic Science Research
- Periodontics and Periodontology
- Medical Microbiology
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Determining Susceptibility and Potential Mediators of Resistance for the Novel Polymyxin Derivative, SPR206, in Acinetobacter baumannii
Abdul-Mutakabbir, J. C., Opoku, N. S., Tan, K. K., Jorth, P., Nizet, V., Fletcher, H. M., Kaye, K. S. & Rybak, M. J., Jan 2024, In: Antibiotics. 13, 1, 47.Research output: Contribution to journal › Article › peer-review
Open Access -
Filifactor alocis enhances survival of Porphyromonas gingivalis W83 in response to H2O2-induced stress
Mishra, A., Dou, Y., Wang, C. & Fletcher, H. M., Feb 2024, In: Molecular Oral Microbiology. 39, 1, p. 12-26 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterization of FA1654: A putative DPS protein in Filifactor alocis
Mangar, M., Mishra, A., Yang, Z., Deivanayagam, C. & Fletcher, H. M., Feb 2023, In: Molecular Oral Microbiology. 38, 1, p. 23-33 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Inhibition of β-lactamase function by de novo designed peptide
Mishra, A., Cosic, I., Loncarevic, I., Cosic, D. & Fletcher, H. M., Sep 2023, In: PLoS ONE. 18, 9 SEPTEMBER, e0290845.Research output: Contribution to journal › Article › peer-review
Open Access -
Local and Systemic Effects of Porphyromonas gingivalis Infection
Chen, W. A., Dou, Y., Fletcher, H. M. & Boskovic, D. S., Feb 2023, In: Microorganisms. 11, 2, 470.Research output: Contribution to journal › Review article › peer-review
Open Access