Systems, Biology, and Bioengineering

Research output

Research output per year 1996 2003 2008 2009 2011 2012 2013 2018 2019 2023

• 123 Article
• 4 Poster
• 3 Chapter
• 2 Other contribution
• 4 More
  • 1 Book
  • 1 Comment/debate
  • 1 Review article
  • 1 Preprint

Research output per year

Research output per year

Search results

• 2023

  Transcriptomic Effects on the Mouse Heart Following 30 Days on the International Space Station

  Veliz, A. L., Mamoun, L., Hughes, L., Vega, R., Holmes, B., Monteon, A., Bray, J., Pecaut, M. J. & Kearns-Jonker, M., Feb 2023, In: Biomolecules. 13, 2, 371.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2022

  Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission

  Holley, J. M., Stanbouly, S., Pecaut, M. J., Willey, J. S., Delp, M. & Mao, X. W., Dec 2022, In: npj Microgravity. 8, 1, 35.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2021

  An Analysis of the Effects of Spaceflight and Vaccination on Antibody Repertoire Diversity

  Rettig, T. A., Tan, J. C., Nishiyama, N. C., Chapes, S. K. & Pecaut, M. J., Aug 1 2021, In: ImmunoHorizons. 5, 8, p. 675-686 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity

  Paul, A. M., Overbey, E. G., da Silveira, W. A., Szewczyk, N., Nishiyama, N. C., Pecaut, M. J., Anand, S., Galazka, J. M. & Mao, X. W., Dec 2021, In: Scientific Reports. 11, 1, 11452.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2020

  Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model

  Mao, X. W., Nishiyama, N. C., Byrum, S. D., Stanbouly, S., Jones, T., Holley, J., Sridharan, V., Boerma, M., Tackett, A. J., Willey, J. S., Pecaut, M. J. & Delp, M. D., Nov 1 2020, In: FASEB Journal. 34, 11, p. 15516-15530 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2019

  A comparison of unamplified and massively multiplexed PCR amplification for murine antibody repertoire sequencing

  Rettig, T. A., Pecaut, M. J. & Chapes, S. K., Jan 2019, In: FASEB BioAdvances. 1, 1, p. 6-17 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations

  Mao, X. W., Nishiyama, N. C., Byrum, S. D., Stanbouly, S., Jones, T., Drew, A., Sridharan, V., Boerma, M., Tackett, A. J., Zawieja, D., Willey, J. S., Delp, M. & Pecaut, M. J., Dec 1 2019, In: Scientific Reports. 9, 1, 8215.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Effects of skeletal unloading on the antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice

  Rettig, T. A., Bye, B. A., Nishiyama, N. C., Hlavacek, S., Ward, C., Pecaut, M. J. & Chapes, S. K., Jan 2019, In: PLoS ONE. 14, 1, e0210284.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Effects of skeletal unloading on the bone marrow antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice

  Rettig, T. A., Nishiyama, N. C., Pecaut, M. J. & Chapes, S. K., Aug 2019, In: Life Sciences in Space Research. 22, p. 16-28 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Proteomic analysis of mouse brain subjected to spaceflight

  Mao, X. W., Sandberg, L. B., Gridley, D. S., Herrmann, E. C., Zhang, G., Raghavan, R., Zubarev, R. A., Zhang, B., Stodieck, L. S., Ferguson, V. L., Bateman, T. A. & Pecaut, M. J., Jan 2019, In: International Journal of Molecular Sciences. 20, 1, 7.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina

  Overbey, E. G., da Silveira, W. A., Stanbouly, S., Nishiyama, N. C., Roque-Torres, G. D., Pecaut, M. J., Zawieja, D. C., Wang, C., Willey, J. S., Delp, M. D., Hardiman, G. & Mao, X. W., Dec 1 2019, In: Scientific Reports. 9, 1, 13304.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The Effects of Simulated Spaceflight Conditions on the Myometrium of the Mouse Uterus

  Elgazzar, A., Forsman, A. D., Mao, X. W., Pecaut, M. J., Nishiyama, N. C., Campbell-Beachler, M. & Mao, X. W., Jan 1 2019, In: Default journal.

  Research output: Contribution to journal › Article › peer-review

• 2018

  Cardiovascular progenitor cells cultured aboard the International Space Station exhibit altered developmental and functional properties

  Baio, J., Martinez, A. F., Silva, I., Hoehn, C. V., Countryman, S., Bailey, L., Hasaniya, N., Pecaut, M. J. & Kearns-Jonker, M., Dec 1 2018, In: npj Microgravity. 4, 1, 13.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing

  Rettig, T. A., Ward, C., Bye, B. A., Pecaut, M. J. & Chapes, S. K., Jan 2018, In: PLoS ONE. 13, 1, e0190982.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice

  Ward, C., Rettig, T. A., Hlavacek, S., Bye, B. A., Pecaut, M. J. & Chapes, S. K., Feb 2018, In: Life Sciences in Space Research. 16, p. 63-75 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Impact of spaceflight and artificial gravity on the mouse retina: Biochemical and proteomic analysis

  Mao, X. W., Byrum, S., Nishiyama, N. C., Pecaut, M. J., Sridharan, V., Boerma, M., Tackett, A. J., Shiba, D., Shirakawa, M., Takahashi, S. & Delp, M. D., Sep 2018, In: International Journal of Molecular Sciences. 19, 9, 2546.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Spaceflight activates protein kinase C alpha signaling and modifies the developmental stage of human neonatal cardiovascular progenitor cells

  Baio, J., Martinez, A. F., Bailey, L., Hasaniya, N., Pecaut, M. J. & Kearns-Jonker, M., Jun 2018, In: Stem Cells and Development. 27, 12, p. 805-818 14 p.

  Research output: Contribution to journal › Article › peer-review

• Vive la radiorésistance! Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization

  Cortese, F., Klokov, D., Osipov, A., Stefaniak, J., Moskalev, A., Schastnaya, J., Cantor, C., Aliper, A., Mamoshina, P., Ushakov, I., Sapetsky, A., Vanhaelen, Q., Alchinova, I., Karganov, M., Kovalchuk, O., Wilkins, R., Shtemberg, A., Moreels, M., Baatout, S., Izumchenko, E., & 10 othersde Magalhães, J. P., Artemov, A. V., Costes, S. V., Beheshti, A., Mao, X. W., Pecaut, M. J., Kaminskiy, D., Ozerov, I. V., Scheibye-Knudsen, M. & Zhavoronkov, A., 2018, In: Oncotarget. 9, 18, p. 14692-14722 31 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2017

  Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism?

  Pecaut, M. J., Mao, X. W., Bellinger, D. L., Jonscher, K. R., Stodieck, L. S., Ferguson, V. L., Bateman, T. A., Mohney, R. P. & Gridley, D. S., Jan 1 2017, In: PLOS ONE. 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism?

  Pecaut, M. J., Mao, X. W., Bellinger, D. L., Jonscher, K. R., Stodieck, L. S., Ferguson, V. L., Bateman, T. A., Mohney, R. P. & Gridley, D. S., May 2017, In: PLoS ONE. 12, 5, e0174174.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Role of NADPH Oxidase as a Mediator of Oxidative Damage in Low-Dose Irradiated and Hindlimb-Unloaded Mice

  Mao, X. W., Nishiyama, N. C., Campbell-Beachler, M., Gifford, P., Haynes, K. E., Gridley, D. S. & Pecaut, M. J., Oct 1 2017, In: Radiation Research. 188, 4, p. 392-399 8 p.

  Research output: Contribution to journal › Article › peer-review

• Spaceflight activates autophagy programs and the proteasome in mouse liver

  Blaber, E. A., Pecaut, M. J. & Jonscher, K. R., Sep 27 2017, In: International Journal of Molecular Sciences. 18, 10, 2062.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The Effects of CDKN1a/p21 on Oxidative Stress and Mitochondrial Function During Long Duration Spaceflight

  Stimpel, O., Almeida, E. A. C., Blaber, E. A., Cheng-Campbell, M. A., Jonscher, K., Pecaut, M., Schrepfer, S. & Pecaut, M. J., Oct 25 2017, In: Default journal.

  Research output: Contribution to journal › Article › peer-review

• Validation of Methods to Assess the Immunoglobulin Gene Repertoire in Tissues Obtained from Mice on the International Space Station

  Rettig, T. A., Ward, C., Pecaut, M. J. & Chapes, S. K., Jul 28 2017, In: Gravitational and Space Research. 5

  Research output: Contribution to journal › Article › peer-review

• 2016

  Changes in the distribution and function of leukocytes after whole-body iron ion irradiation

  Gridley, D. S. & Pecaut, M. J., Sep 1 2016, In: Journal of Radiation Research. 57, 5, p. 477-491 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Correction: Spaceflight Activates Lipotoxic Pathways in Mouse Liver

  Jonscher, K. R., Alfonso-Garcia, A., Suhalim, J. L., Orlicky, D. J., Potma, E. O., Ferguson, V. L., Bouxsein, M. L., Bateman, T. A., Stodieck, L. S., Levi, M., Friedman, J. E., Gridley, D. S. & Pecaut, M. J., May 4 2016, In: PLOS ONE. 11

  Research output: Contribution to journal › Article › peer-review

• Simulated Microgravity and Low-Dose/Low-Dose-Rate Radiation Induces Oxidative Damage in the Mouse Brain

  Mao, X. W., Nishiyama, N. C., Pecaut, M. J., Campbell-Beachler, M., Gifford, P., Haynes, K. E., Becronis, C. & Gridley, D. S., Jun 2016, In: Radiation Research. 185, 6, p. 647-657 11 p.

  Research output: Contribution to journal › Article › peer-review

• Spaceflight activates lipotoxic pathways in mouse liver

  Jonscher, K. R., Alfonso-Garcia, A., Suhalim, J. L., Orlicky, D. J., Potma, E. O., Ferguson, V. L., Bouxsein, M. L., Bateman, T. A., Stodieck, L. S., Levi, M., Friedman, J. E., Gridley, D. S. & Pecaut, M. J., Apr 2016, In: PLoS ONE. 11, 4, e0152877.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Spaceflight Activates Lipotoxic Pathways in Mouse Liver.

  Jonscher, K. R., Alfonso-Garcia, A., Suhalim, J. L., Orlicky, D. J., Potma, E. O., Ferguson, V. L., Bouxsein, M. L., Bateman, T. A., Stodieck, L. S., Levi, M., Friedman, J. E., Gridley, D. S. & Pecaut, M. J., Jan 1 2016, In: PLOS ONE. 11

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2015

  Chlorisondamine, a sympathetic ganglionic blocker, moderates the effects of whole-body irradiation (WBI) on early host defense to a live bacterial challenge

  Pecaut, M. J., Mehrotra, S., Luo-Owen, X., Bayeta, E. J. M., Bellinger, D. L. & Gridley, D. S., Oct 1 2015, In: Immunology Letters. 167, 2, p. 103-115 13 p.

  Research output: Contribution to journal › Article › peer-review

• Effects of targeted proton radiation on spinal cord in a porcine model: A pilot study

  Mao, X. W., Pecaut, M. J., Cao, J. D. & Gridley, D. S., Nov 1 2015, In: In Vivo. 29, 6, p. 651-659 9 p.

  Research output: Contribution to journal › Article › peer-review

• Effects of Targeted Proton Radiation on Spinal Cord in a Porcine Model: A Pilot Study.

  Mao, X. W., Pecaut, M. J., Cao, J. D. & Gridley, D. S., Jan 1 2015, In: in Vivo. 29

  Research output: Contribution to journal › Article › peer-review

• Genetic and apoptotic changes in lungs of mice flown on the STS-135 mission in space

  Gridley, D. S., Mao, X. W., Tian, J., Cao, J. D., Perez, C., Stodieck, L. S., Ferguson, V. L., Bateman, T. A. & Pecaut, M. J., Jul 1 2015, In: In Vivo. 29, 4, p. 423-433 11 p.

  Research output: Contribution to journal › Article › peer-review

• Spaceflight effects on T lymphocyte distribution, function and gene expression

  Stodieck, L. S., Ferguson, V. L., Pecaut, M. J., Gridley, D. S., Slater, J. M., Luo-Owen, X., Rizvi, A., Sonnenfeld, G., Motamedifar, M., Namdari, G., Taheri, M., Shokrpour, N., Nelson, G. A., Eisch, A. J., Latchney, S. E., Rivera, P. D., Mao, X. W. & Bateman, T. A., Jan 1 2015, In: Journal of Applied Physiology. 106

  Research output: Contribution to journal › Article › peer-review

• 2014

  115. “Inflammaging” and psychosocial stress in a murine orthotopic prostate cancer model

  Bellinger, D. L., Molinaro, C., Gifford, P., Dulcich, M. S., Hartman, R. E., Pecaut, M. J., Lorton, D., Gridley, D. S. & Gridley, D. S., Jan 9 2014, In: Brain Behavior and Immunity. 40

  Research output: Contribution to journal › Article › peer-review

• 28. The effects of the spaceflight environment on stress pathways

  Pecaut, M. J., Bellinger, D. L., Mao, X. W., Stodieck, L. S., Ferguson, V. L., Bateman, T. A., Gifford, P. S., Bayeta, E. J., Jones, T. A., Gridley, D. S. & Gridley, D. S., Jan 9 2014, In: Brain Behavior and Immunity. 40

  Research output: Contribution to journal › Article › peer-review

• Biological and metabolic response in STS-135 space-flown mouse skin

  Mao, X. W., Pecaut, M. J., Stodieck, L. S., Ferguson, V. L., Bateman, T. A., Bouxsein, M. L. & Gridley, D. S., Aug 2014, In: Free Radical Research. 48, 8, p. 890-897 8 p.

  Research output: Contribution to journal › Article › peer-review

• Biological effects of passive versus active scanning proton beams on human lung epithelial cells

  Gridley, D. S., Pecaut, M. J., Mao, X. W., Wroe, A. J. & Luo-owen, X., 2014, In: Technology in Cancer Research and Treatment. 14, 1, p. 81-98 18 p.

  Research output: Contribution to journal › Article › peer-review

• Impact of total-body irradiation on the response to a live bacterial challenge

  Pecaut, M. J., Baqai, F. P. & Gridley, D. S., 2014, In: International Journal of Radiation Biology. 90, 7, p. 515-526 12 p.

  Research output: Contribution to journal › Article › peer-review

• Minocycline modulates cytokine and gene expression profiles in the brain after whole-body exposure to radiation

  Mehrotra, S., Pecaut, M. J. & Gridley, D. S., 2014, In: In Vivo. 28, 1, p. 21-32 12 p.

  Research output: Contribution to journal › Article › peer-review
• 2013

  Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space

  Gridley, D. S., Mao, X. W., Stodieck, L. S., Ferguson, V. L., Bateman, T. A., Moldovan, M., Cunningham, C. E., Jones, T. A., Slater, J. M. & Pecaut, M. J., Sep 19 2013, In: PLoS ONE. 8, 9, e75097.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Correction: Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space

  Gridley, D. S., Mao, X. W., Stodieck, L. S., Ferguson, V. L., Bateman, T. A., Moldovan, M., Cunningham, C. E., Jones, T. A., Slater, J. M. & Pecaut, M. J., Sep 27 2013, In: PLOS ONE. 8

  Research output: Contribution to journal › Article › peer-review

• Effects of minocycline on hematopoietic recovery after whole-body irradiation

  Mehrotra, S., Pecaut, M. J. & Gridley, D. S., 2013, In: In Vivo. 27, 1, p. 11-28 18 p.

  Research output: Contribution to journal › Article › peer-review

• Effects of Space Flight on the Expression of Liver Proteins in the Mouse

  Gridley, D. S., Pecaut, M. J., Green, L. M., Herrmann, E. C., Bianski, B., Slater, J. M., Stodieck, L. S., Ferguson, V. L., Sandberg, L. B. & Sandberg, L., May 1 2013, In: Journal of biomolecular techniques. 24

  Research output: Contribution to journal › Article › peer-review

• Low-dose radiation modifies skin response to acute gamma-rays and protons

  Mao, X. W., Pecaut, M. J., Cao, J. D., Moldovan, M. & Gridley, D. S., 2013, In: In Vivo. 27, 6, p. 695-700 6 p.

  Research output: Contribution to journal › Article › peer-review

• Protracted low-dose radiation priming and response of liver to acute gamma and proton radiation.

  Gridley, D. S., Mao, X. W., Cao, J. D., Bayeta, E. J. & Pecaut, M. J., Oct 2013, In: Free Radical Research. 47, 10, p. 811-820 10 p.

  Research output: Contribution to journal › Article › peer-review

• Spaceflight environment induces mitochondrial oxidative damage in ocular tissue

  Mao, X. W., Pecaut, M. J., Stodieck, L. S., Ferguson, V. L., Bateman, T. A., Bouxsein, M., Jones, T. A., Moldovan, M., Cunningham, C. E., Chieu, J. & Gridley, D. S., Oct 2013, In: Radiation Research. 180, 4, p. 340-350 11 p.

  Research output: Contribution to journal › Article › peer-review

• Space-relevant radiation modifies cytokine profiles, signaling proteins and Foxp3⁺ T cells

  Gridley, D. S., Rizvi, A., Makinde, A. Y., Luo-Owen, X., Mao, X. W., Tian, J., Slater, J. M. & Pecaut, M. J., Jan 2013, In: International Journal of Radiation Biology. 89, 1, p. 26-35 10 p.

  Research output: Contribution to journal › Article › peer-review

• Therapeutic Utilities of SOD Mimetics: Cancer, Radiotherapy and SOD Mimetics

  Gridley, D. S., Green, L. M., Nelson, G. A., Pecaut, M. J., Slater, J. M. & Nelson, G., Jan 1 2013, In: In: Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013. Available from: https://www.ncbi.nlm.nih.gov/books/NBK6099/.

  Research output: Contribution to journal › Article › peer-review

• 2012

  133. Age and psychosocial stress affect depression and anxiety-related behaviors, tumor growth and leukocyte infiltration in an orthotopic mouse model of prostate cancer

  Bellinger, D. L., Dulcich, M. S., Gifford, P. S., Molinaro, C. A., Gridley, D. S., Lorton, D., Pecaut, M. J., Hartman, R. E. & Gridley, D. S., Sep 1 2012, In: Brain Behavior and Immunity. 26

  Research output: Contribution to journal › Article › peer-review