TY - JOUR
T1 - Wear of ultra-high molecular weight polyethylene and polytetrafluoroethylene in a hip simulator
T2 - A dose-response study of protein concentration
AU - Good, Victoria D.
AU - Clarke, Ian C.
AU - Gustafson, G. Allen
AU - Downs, Brandon
AU - Anissian, Lucas
AU - Sorensen, Kim
N1 - Funding Information:
This study was supported by Loma Linda University Medical Center,a d tnhe Dpartmenet of Orthopaedics, LLUMC. Weta hkKrnassimir Bozhilov at the University of California Riverside for help with the scanning electron microscope, as well as D.S .Nriocl, Professor J. Paul and Professor Barbenel (Strathclyde University) for their invaluable advice. Thanks are also due to the following: Peggy Stark and Ron Moran (Moran Innovations) for their assistance, D.St evre Li athte H ospital for Special Surgery for the polyethylene and Protek Inc. for donation of the CoCr femoral heads.
PY - 2000
Y1 - 2000
N2 - Charnley's laboratory, wear studies of non-gamma sterilized polytetrafluoroethylene (PTFE) and polyethylene (PE) found that the PTFE to PE wearrate ratio of 250:1 was much higher than the in-vivo wear ratio of 20:1. Tests of PTFE and PE in our laboratory showed a wear ratio of 150:1, using bovine serum as the lubricant and 190:1 with water as the lubricant. Our hypothesis was that the wear-rates of PTFE and PE cup materials were related to the concentration of protein in the serum. We studied the wear behavior of PTFE and PE cups in varied protein concentrations, using 4 femoral head sizes to validate the clinical range reported by Charnley. The PTFE wear-rates increased with increasing protein concentration and conversely, PE wear-rates decreased with increasing protein concentration. This inverse relationship made it possible to bring the wear ratio closer to the desired clinical wear ratio. We found that the clinically relevant PTFE/PE wear ratio corresponded to 3-10 mg/mL of protein in bovine serum.
AB - Charnley's laboratory, wear studies of non-gamma sterilized polytetrafluoroethylene (PTFE) and polyethylene (PE) found that the PTFE to PE wearrate ratio of 250:1 was much higher than the in-vivo wear ratio of 20:1. Tests of PTFE and PE in our laboratory showed a wear ratio of 150:1, using bovine serum as the lubricant and 190:1 with water as the lubricant. Our hypothesis was that the wear-rates of PTFE and PE cup materials were related to the concentration of protein in the serum. We studied the wear behavior of PTFE and PE cups in varied protein concentrations, using 4 femoral head sizes to validate the clinical range reported by Charnley. The PTFE wear-rates increased with increasing protein concentration and conversely, PE wear-rates decreased with increasing protein concentration. This inverse relationship made it possible to bring the wear ratio closer to the desired clinical wear ratio. We found that the clinically relevant PTFE/PE wear ratio corresponded to 3-10 mg/mL of protein in bovine serum.
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U2 - 10.1080/000164700317393358
DO - 10.1080/000164700317393358
M3 - Article
C2 - 11028884
SN - 0001-6470
VL - 71
SP - 365
EP - 369
JO - Acta Orthopaedica Scandinavica
JF - Acta Orthopaedica Scandinavica
IS - 4
ER -