TY - JOUR
T1 - The role of thromboinflammation in delayed cerebral ischemia after subarachnoid hemorrhage
AU - McBride, Devin W.
AU - Blackburn, Spiros L.
AU - Peeyush Kumar, T.
AU - Matsumura, Kanako
AU - Zhang, John H.
N1 - Publisher Copyright:
© 2017 McBride, Blackburn, Peeyush, Matsumura and Zhang.
PY - 2017/10/23
Y1 - 2017/10/23
N2 - Delayed cerebral ischemia (DCI) is a major determinant of patient outcome following aneurysmal subarachnoid hemorrhage. Although the exact mechanisms leading to DCI are not fully known, inflammation, cerebral vasospasm, and microthrombi may all function together to mediate the onset of DCI. Indeed, inflammation is tightly linked with activation of coagulation and microthrombi formation. Thromboinflammation is the intersection at which inflammation and thrombosis regulate one another in a feedforward manner, potentiating the formation of thrombi and pro-inflammatory signaling. In this review, we will explore the role(s) of inflammation and microthrombi in subarachnoid hemorrhage (SAH) pathophysiology and DCI, and discuss the potential of targeting thromboinflammation to prevent DCI after SAH.
AB - Delayed cerebral ischemia (DCI) is a major determinant of patient outcome following aneurysmal subarachnoid hemorrhage. Although the exact mechanisms leading to DCI are not fully known, inflammation, cerebral vasospasm, and microthrombi may all function together to mediate the onset of DCI. Indeed, inflammation is tightly linked with activation of coagulation and microthrombi formation. Thromboinflammation is the intersection at which inflammation and thrombosis regulate one another in a feedforward manner, potentiating the formation of thrombi and pro-inflammatory signaling. In this review, we will explore the role(s) of inflammation and microthrombi in subarachnoid hemorrhage (SAH) pathophysiology and DCI, and discuss the potential of targeting thromboinflammation to prevent DCI after SAH.
KW - Cerebral vasospasm
KW - Delayed cerebral ischemia
KW - Inflammation
KW - Subarachnoid hemorrhage
KW - Thromboinflammation
KW - Thrombosis
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UR - http://www.scopus.com/inward/citedby.url?scp=85032215455&partnerID=8YFLogxK
U2 - 10.3389/fneur.2017.00555
DO - 10.3389/fneur.2017.00555
M3 - Short survey
SN - 1664-2295
VL - 8
JO - Frontiers in Neurology
JF - Frontiers in Neurology
IS - OCT
M1 - 555
ER -