TY - JOUR
T1 - The role of TGF-beta signaling in dendritic cell tolerance
AU - Esebanmen, Grace E.
AU - Langridge, William H.R.
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Transforming growth factor beta (TGF-β) is a pleiotropic cytokine present in vertebrate and invertebrate organisms that functions in numerous physiological and pathological processes. TGF-β impacts all the cells of the immune system, and of the three known TGF-β isoforms, TGF-β1 is the predominant isoform expressed in immune cells. TGF-β1 is known to play a pivotal role in the function of all immune cells especially in the regulation of T cell development and in the induction of immunological tolerance in dendritic cells (DCs). Based on the importance of DCs in regulation of the innate and adaptive arms of the immune system, in this review we explore the regulatory functions of TGF-β required for establishment and maintenance of DC-mediated immune tolerance.
AB - Transforming growth factor beta (TGF-β) is a pleiotropic cytokine present in vertebrate and invertebrate organisms that functions in numerous physiological and pathological processes. TGF-β impacts all the cells of the immune system, and of the three known TGF-β isoforms, TGF-β1 is the predominant isoform expressed in immune cells. TGF-β1 is known to play a pivotal role in the function of all immune cells especially in the regulation of T cell development and in the induction of immunological tolerance in dendritic cells (DCs). Based on the importance of DCs in regulation of the innate and adaptive arms of the immune system, in this review we explore the regulatory functions of TGF-β required for establishment and maintenance of DC-mediated immune tolerance.
KW - Dendritic cells
KW - Immunological tolerance
KW - T cells
KW - TGF-β signaling
UR - http://www.scopus.com/inward/record.url?scp=85028577864&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028577864&partnerID=8YFLogxK
U2 - 10.1007/s12026-017-8944-9
DO - 10.1007/s12026-017-8944-9
M3 - Review article
C2 - 28845509
SN - 0257-277X
VL - 65
SP - 987
EP - 994
JO - Immunologic Research
JF - Immunologic Research
IS - 5
ER -