TY - JOUR
T1 - The obesity-impulsivity axis
T2 - Potential metabolic interventions in chronic psychiatric patients
AU - Sfera, Adonis
AU - Osorio, Carolina
AU - Inderias, Luzmin Acosta
AU - Parker, Victoria
AU - Price, Amy I.
AU - Cummings, Michael
N1 - Publisher Copyright:
© 2017 Sfera, Osorio, Inderias, Parker, Price and Cummings.
PY - 2017/2/13
Y1 - 2017/2/13
N2 - Pathological impulsivity is encountered in a broad range of psychiatric conditions and is thought to be a risk factor for aggression directed against oneself or others. Recently, a strong association was found between impulsivity and obesity which may explain the high prevalence of metabolic disorders in individuals with mental illness even in the absence of exposure to psychotropic drugs. As the overlapping neurobiology of impulsivity and obesity is being unraveled, the question asked louder and louder is whether they should be treated concomitantly. The treatment of obesity and metabolic dysregulations in chronic psychiatric patients is currently underutilized and often initiated late, making correction more difficult to achieve. Addressing obesity and metabolic dysfunction in a preventive manner may not only lower morbidity and mortality but also the excessive impulsivity, decreasing the risk for aggression. In this review, we take a look beyond psychopharmacological interventions and discuss dietary and physical therapy approaches.
AB - Pathological impulsivity is encountered in a broad range of psychiatric conditions and is thought to be a risk factor for aggression directed against oneself or others. Recently, a strong association was found between impulsivity and obesity which may explain the high prevalence of metabolic disorders in individuals with mental illness even in the absence of exposure to psychotropic drugs. As the overlapping neurobiology of impulsivity and obesity is being unraveled, the question asked louder and louder is whether they should be treated concomitantly. The treatment of obesity and metabolic dysregulations in chronic psychiatric patients is currently underutilized and often initiated late, making correction more difficult to achieve. Addressing obesity and metabolic dysfunction in a preventive manner may not only lower morbidity and mortality but also the excessive impulsivity, decreasing the risk for aggression. In this review, we take a look beyond psychopharmacological interventions and discuss dietary and physical therapy approaches.
KW - Acetylcholine
KW - Impulsivity
KW - Microbiome
KW - Monoamines
KW - Short-chain fatty acids
UR - http://www.scopus.com/inward/record.url?scp=85014134332&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014134332&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2017.00020
DO - 10.3389/fpsyt.2017.00020
M3 - Review article
SN - 1664-0640
VL - 8
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
IS - FEB
M1 - 20
ER -