TY - JOUR
T1 - The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease.
AU - Currais, Antonio
AU - Hortobágyi, Tibor
AU - Soriano, Salvador
PY - 2009/4
Y1 - 2009/4
N2 - Differentiated neurons display specific biochemical, physiological and morphological properties that apparently prevent them from further cell division. Nevertheless, expression of cell cycle modulators persists after neuronal differentiation and is upregulated under stress conditions, such as trophic factor deprivation, oxidative stress and the presence of DNA damaging agents. This apparent reactivation of the cell cycle has been postulated as a sine qua non for neuronal death in response to those stress conditions, particularly in Alzheimer's disease. However, the physiological and pathogenic implications of a putative neuronal cell cycle are far from clear. Here, we discuss the notion of the neuronal cell cycle as a mediator of cell death, with particular emphasis on Alzheimer's disease.
AB - Differentiated neurons display specific biochemical, physiological and morphological properties that apparently prevent them from further cell division. Nevertheless, expression of cell cycle modulators persists after neuronal differentiation and is upregulated under stress conditions, such as trophic factor deprivation, oxidative stress and the presence of DNA damaging agents. This apparent reactivation of the cell cycle has been postulated as a sine qua non for neuronal death in response to those stress conditions, particularly in Alzheimer's disease. However, the physiological and pathogenic implications of a putative neuronal cell cycle are far from clear. Here, we discuss the notion of the neuronal cell cycle as a mediator of cell death, with particular emphasis on Alzheimer's disease.
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U2 - 10.18632/aging.100045
DO - 10.18632/aging.100045
M3 - Review article
C2 - 20157524
SN - 1945-4589
VL - 1
SP - 363
EP - 371
JO - Aging
JF - Aging
IS - 4
ER -