The dual role of microglia in blood-brain barrier dysfunction after stroke

Ruiqing Kang; Marcin Gamdzyk; Cameron Lenahan; Jiping Tang; Sheng Tan; John H. Zhang

doi:10.2174/1570159X18666200529150907

The dual role of microglia in blood-brain barrier dysfunction after stroke

Ruiqing Kang, Marcin Gamdzyk, Cameron Lenahan, Jiping Tang, Sheng Tan, John H. Zhang

Research output: Contribution to journal › Review article › peer-review

Abstract

It is well-known that stroke is one of the leading causes of death and disability all over the world. After a stroke, the blood-brain barrier subsequently breaks down. The BBB consists of endothelial cells surrounded by astrocytes. Microglia, considered the long-living resident immune cells of the brain, play a vital role in BBB function. M1 microglia worsen BBB disruption, while M2 microglia assist in repairing BBB damage. Microglia can also directly interact with endothelial cells and affect BBB permeability. In this review, we are going to discuss the mechanisms respon-sible for the dual role of microglia in BBB dysfunction after stroke.

Original language	English
Pages (from-to)	1237-1249
Number of pages	13
Journal	Current Neuropharmacology
Volume	18
Issue number	12
DOIs	https://doi.org/10.2174/1570159X18666200529150907
State	Published - 2020

ASJC Scopus Subject Areas

Pharmacology
Neurology
Clinical Neurology
Psychiatry and Mental health
Pharmacology (medical)

Keywords

Blood-brain barrier
Endothelial cells
Inflammation
Microglia
Polarization
Stroke

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title = "The dual role of microglia in blood-brain barrier dysfunction after stroke",

abstract = "It is well-known that stroke is one of the leading causes of death and disability all over the world. After a stroke, the blood-brain barrier subsequently breaks down. The BBB consists of endothelial cells surrounded by astrocytes. Microglia, considered the long-living resident immune cells of the brain, play a vital role in BBB function. M1 microglia worsen BBB disruption, while M2 microglia assist in repairing BBB damage. Microglia can also directly interact with endothelial cells and affect BBB permeability. In this review, we are going to discuss the mechanisms respon-sible for the dual role of microglia in BBB dysfunction after stroke.",

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AU - Lenahan, Cameron

AU - Tang, Jiping

AU - Tan, Sheng

AU - Zhang, John H.

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KW - Endothelial cells

KW - Inflammation

KW - Microglia

KW - Polarization

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The dual role of microglia in blood-brain barrier dysfunction after stroke

Abstract

ASJC Scopus Subject Areas

Keywords

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