Abstract
Activation of the unfolded protein response in combination with generation of reactive oxygen species, from cytochrome P450 members and NADPH-P450 reductases, are two major consequences of Endoplasmic Reticulum (ER) stress that cause oxidative damage and cell death. Herein, we reviewed the role of Bax Inhibitor-1 (BI-1), an evolutionarily conserved protein encoded by the Transmembrane Bax inhibitor Motif Containing 6 gene, in protection from ER stress. As BI-1 has multimodal properties that can target a wide array of pathophysiological consequences after injury, our main objective was to explore BI-1's protective role in ER stress and its potential signaling pathways.
Original language | English |
---|---|
Pages (from-to) | 77-86 |
Number of pages | 10 |
Journal | Journal of Neuroscience Research |
Volume | 98 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2020 |
ASJC Scopus Subject Areas
- Cellular and Molecular Neuroscience
Keywords
- BI-1
- ER stress
- apoptosis
- oxidative stress