TY - JOUR
T1 - The association between ambient fine particulate matter and incident adenocarcinoma subtype of lung cancer
AU - Gharibvand, Lida
AU - Lawrence Beeson, W.
AU - Shavlik, David
AU - Knutsen, Raymond
AU - Ghamsary, Mark
AU - Soret, Samuel
AU - Knutsen, Synnove F.
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2017/6/24
Y1 - 2017/6/24
N2 - Background: Adenocarcinoma (AC) is the most common lung cancer among non-smokers, but few studies have assessed the effect of PM2.5 on AC among never smokers. The purpose of this study was to assess the association between ambient PM2.5 and incident lung AC in the Adventist Health and Smog Study-2 (AHSMOG-2), a cohort of 80,044 non-smokers (81% never smokers) followed for 7.5 years (597,177 person-years) (2002-2011). Methods: Incident lung AC was identified through linkage with U.S. state cancer registries. Ambient PM2.5 levels at subjects' residences were estimated for the years 2000 and 2001, immediately prior to study start. Results: A total of 164 incident lung AC occurred during follow-up. Each 10 μg/m3 increment in PM2.5 was associated with an increase in the hazard rate of lung AC [HR = 1.31 (95% confidence interval (CI) 0.87-1.97)] in the single-pollutant model. Excluding those with prevalent non-melanoma skin cancer (NMSC) strengthened the association with lung AC (HR = 1.62 (95% CI, 1.11-2.36) for each 10 μg/m3 PM2.5 increment. Also, limiting the analyses to subjects who spent more than 1 h/day outdoors, increased the estimate (HR = 1.55, 95% CI: 1.05, 2.30). Conclusions: Increased risk of AC was observed for each 10 μg/m3 increment in ambient PM2.5 concentrations. The risk was higher among those without prevalent NMSC and those who spent more than 1 h/day outdoors.
AB - Background: Adenocarcinoma (AC) is the most common lung cancer among non-smokers, but few studies have assessed the effect of PM2.5 on AC among never smokers. The purpose of this study was to assess the association between ambient PM2.5 and incident lung AC in the Adventist Health and Smog Study-2 (AHSMOG-2), a cohort of 80,044 non-smokers (81% never smokers) followed for 7.5 years (597,177 person-years) (2002-2011). Methods: Incident lung AC was identified through linkage with U.S. state cancer registries. Ambient PM2.5 levels at subjects' residences were estimated for the years 2000 and 2001, immediately prior to study start. Results: A total of 164 incident lung AC occurred during follow-up. Each 10 μg/m3 increment in PM2.5 was associated with an increase in the hazard rate of lung AC [HR = 1.31 (95% confidence interval (CI) 0.87-1.97)] in the single-pollutant model. Excluding those with prevalent non-melanoma skin cancer (NMSC) strengthened the association with lung AC (HR = 1.62 (95% CI, 1.11-2.36) for each 10 μg/m3 PM2.5 increment. Also, limiting the analyses to subjects who spent more than 1 h/day outdoors, increased the estimate (HR = 1.55, 95% CI: 1.05, 2.30). Conclusions: Increased risk of AC was observed for each 10 μg/m3 increment in ambient PM2.5 concentrations. The risk was higher among those without prevalent NMSC and those who spent more than 1 h/day outdoors.
KW - Adventists
KW - Air pollution
KW - Lung adenocarcinoma
KW - Lung cancer
KW - Non-melanoma skin cancer
KW - Non-smokers
KW - Particulate matter
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U2 - 10.1186/s12940-017-0268-7
DO - 10.1186/s12940-017-0268-7
M3 - Article
C2 - 28646928
SN - 1476-069X
VL - 16
JO - Environmental Health: A Global Access Science Source
JF - Environmental Health: A Global Access Science Source
IS - 1
M1 - 71
ER -