TY - JOUR
T1 - Sympathetic modulation of immunity
T2 - Relevance to disease
AU - Bellinger, Denise L.
AU - Millar, Brooke A.
AU - Perez, Sam
AU - Carter, Jeff
AU - Wood, Carlo
AU - ThyagaRajan, Srinivasan
AU - Molinaro, Christine
AU - Lubahn, Cheri
AU - Lorton, Dianne
N1 - Cell Immunol. 2008 Mar-Apr;252(1-2):27-56. doi: 10.1016/j.cellimm.2007.09.005. Epub 2008 Mar 4. Review
PY - 2008
Y1 - 2008
N2 - Optimal host defense against pathogens requires cross-talk between the nervous and immune systems. This paper reviews sympathetic-immune interaction, one major communication pathway, and its importance for health and disease. Sympathetic innervation of primary and secondary immune organs is described, as well as evidence for neurotransmission with cells of the immune system as targets. Most research thus far has focused on neural-immune modulation in secondary lymphoid organs, has revealed complex sympathetic modulation resulting in both potentiation and inhibition of immune functions. SNS-immune interaction may enhance immune readiness during disease- or injury-induced 'fight' responses. Research also indicate that dysregulation of the SNS can significantly affect the progression of immune-mediated diseases. However, a better understanding of neural-immune interactions is needed to develop strategies for treatment of immune-mediated diseases that are designed to return homeostasis and restore normal functioning neural-immune networks.
AB - Optimal host defense against pathogens requires cross-talk between the nervous and immune systems. This paper reviews sympathetic-immune interaction, one major communication pathway, and its importance for health and disease. Sympathetic innervation of primary and secondary immune organs is described, as well as evidence for neurotransmission with cells of the immune system as targets. Most research thus far has focused on neural-immune modulation in secondary lymphoid organs, has revealed complex sympathetic modulation resulting in both potentiation and inhibition of immune functions. SNS-immune interaction may enhance immune readiness during disease- or injury-induced 'fight' responses. Research also indicate that dysregulation of the SNS can significantly affect the progression of immune-mediated diseases. However, a better understanding of neural-immune interactions is needed to develop strategies for treatment of immune-mediated diseases that are designed to return homeostasis and restore normal functioning neural-immune networks.
KW - Autonomic
KW - Immune modulation
KW - Lymphoid organs
KW - Noradrenergic
KW - Sympathetic innervation
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U2 - 10.1016/j.cellimm.2007.09.005
DO - 10.1016/j.cellimm.2007.09.005
M3 - Review article
C2 - 18308299
SN - 0008-8749
VL - 252
SP - 27
EP - 56
JO - Cellular Immunology
JF - Cellular Immunology
IS - 1-2
ER -