TY - JOUR
T1 - Surgically-induced brain injury
T2 - Where are we now?
AU - Travis, Zachary D.
AU - Sherchan, Prativa
AU - Hayes, William K.
AU - Zhang, John H.
N1 - Publisher Copyright:
© 2019 The Author(s).
PY - 2019/12/16
Y1 - 2019/12/16
N2 - Neurosurgical procedures cause inevitable brain damage from the multitude of surgical manipulations utilized. Incisions, retraction, thermal damage from electrocautery, and intraoperative hemorrhage cause immediate and long-Term brain injuries that are directly linked to neurosurgical operations, and these types of injuries, collectively, have been termed surgical brain injury (SBI). For the past decade, a model developed to study the underlying brain pathologies resulting from SBI has provided insight on cellular mechanisms and potential therapeutic targets. This model, as seen in a rat, mouse, and rabbit, mimics a neurosurgical operation and causes commonly encountered post-operative complications such as brain edema, neuroinflammation, and hemorrhage. In this review, we elaborate on SBI and its clinical impact, the SBI animal models and their clinical relevance, the importance of applying therapeutics before neurosurgical procedures (i.e., preconditioning), and the new direction of applying venom-derived proteins to attenuate SBI.
AB - Neurosurgical procedures cause inevitable brain damage from the multitude of surgical manipulations utilized. Incisions, retraction, thermal damage from electrocautery, and intraoperative hemorrhage cause immediate and long-Term brain injuries that are directly linked to neurosurgical operations, and these types of injuries, collectively, have been termed surgical brain injury (SBI). For the past decade, a model developed to study the underlying brain pathologies resulting from SBI has provided insight on cellular mechanisms and potential therapeutic targets. This model, as seen in a rat, mouse, and rabbit, mimics a neurosurgical operation and causes commonly encountered post-operative complications such as brain edema, neuroinflammation, and hemorrhage. In this review, we elaborate on SBI and its clinical impact, the SBI animal models and their clinical relevance, the importance of applying therapeutics before neurosurgical procedures (i.e., preconditioning), and the new direction of applying venom-derived proteins to attenuate SBI.
KW - Brain injury
KW - Cerebral edema
KW - Neurotherapeutics
KW - Preconditioning
KW - Venom therapies
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U2 - 10.1186/s41016-019-0181-8
DO - 10.1186/s41016-019-0181-8
M3 - Review article
SN - 2057-4967
VL - 5
JO - Chinese Neurosurgical Journal
JF - Chinese Neurosurgical Journal
IS - 1
M1 - 29
ER -