TY - JOUR
T1 - Rhodopsin
T2 - A Potential Biomarker for Neurodegenerative Diseases
AU - Lenahan, Cameron
AU - Sanghavi, Rajvee
AU - Huang, Lei
AU - Zhang, John H.
N1 - Publisher Copyright:
© Copyright © 2020 Lenahan, Sanghavi, Huang and Zhang.
PY - 2020/4/15
Y1 - 2020/4/15
N2 - Retinal alterations have recently been associated with numerous neurodegenerative diseases. Rhodopsin is a G-protein coupled receptor found in the rod cells of the retina. As a biomarker associated with retinal thinning and degeneration, it bears potential in the early detection and monitoring of several neurodegenerative diseases. In this review article, we summarize the findings of correlations between rhodopsin and several neurodegenerative disorders as well as the potential of a novel technique, cSLO, in the quantification of rhodopsin.
AB - Retinal alterations have recently been associated with numerous neurodegenerative diseases. Rhodopsin is a G-protein coupled receptor found in the rod cells of the retina. As a biomarker associated with retinal thinning and degeneration, it bears potential in the early detection and monitoring of several neurodegenerative diseases. In this review article, we summarize the findings of correlations between rhodopsin and several neurodegenerative disorders as well as the potential of a novel technique, cSLO, in the quantification of rhodopsin.
KW - Alzheimer’s disease
KW - Huntington’s disease
KW - Parkinson’s disease
KW - amyotrophic lateral sclerosis
KW - confocal scanning laser ophthalmoscopy
KW - rhodopsin
UR - http://www.scopus.com/inward/record.url?scp=85084004123&partnerID=8YFLogxK
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U2 - 10.3389/fnins.2020.00326
DO - 10.3389/fnins.2020.00326
M3 - Review article
SN - 1662-4548
VL - 14
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
M1 - 326
ER -