Response to Letter Regarding Article, "norrin Protected Blood-Brain Barrier via Frizzled-4/β-Catenin Pathway after Subarachnoid Hemorrhage in Rats"

Yujie Chen; Hua Feng; John H. Zhang

doi:10.1161/STROKEAHA.115.008779

Response to Letter Regarding Article, "norrin Protected Blood-Brain Barrier via Frizzled-4/β-Catenin Pathway after Subarachnoid Hemorrhage in Rats"

Yujie Chen, Hua Feng, John H. Zhang

Research output: Contribution to journal › Letter › peer-review

Original language	English
Pages (from-to)	e91
Journal	Stroke
Volume	46
Issue number	4
DOIs	https://doi.org/10.1161/STROKEAHA.115.008779
State	Published - Apr 20 2015

ASJC Scopus Subject Areas

Clinical Neurology
Cardiology and Cardiovascular Medicine
Advanced and Specialized Nursing

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10.1161/STROKEAHA.115.008779

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@article{585ba2a91d8c4788914b4ada22adc025,

title = "Response to Letter Regarding Article, {"}norrin Protected Blood-Brain Barrier via Frizzled-4/β-Catenin Pathway after Subarachnoid Hemorrhage in Rats{"}",

author = "Yujie Chen and Hua Feng and Zhang, {John H.}",

note = "We appreciate Zuo and Xu1 for their interest in our study and their concerns about the frizzled-4 small interfering RNA (siRNA) efficacy in our experiments. We concur that the magnitude of suppression of siRNA in vivo was less than that achieved in vitro, therefore we used a pool of 3 different frizzled-4 siRNA duplexes to improve the knockdown efficiency.",

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T1 - Response to Letter Regarding Article, "norrin Protected Blood-Brain Barrier via Frizzled-4/β-Catenin Pathway after Subarachnoid Hemorrhage in Rats"

AU - Chen, Yujie

AU - Feng, Hua

AU - Zhang, John H.

N1 - We appreciate Zuo and Xu1 for their interest in our study and their concerns about the frizzled-4 small interfering RNA (siRNA) efficacy in our experiments. We concur that the magnitude of suppression of siRNA in vivo was less than that achieved in vitro, therefore we used a pool of 3 different frizzled-4 siRNA duplexes to improve the knockdown efficiency.

PY - 2015/4/20

Y1 - 2015/4/20

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U2 - 10.1161/STROKEAHA.115.008779

DO - 10.1161/STROKEAHA.115.008779

M3 - Letter

C2 - 25721016

SN - 0039-2499

VL - 46

SP - e91

JO - Stroke

JF - Stroke

IS - 4

ER -

Response to Letter Regarding Article, "norrin Protected Blood-Brain Barrier via Frizzled-4/β-Catenin Pathway after Subarachnoid Hemorrhage in Rats"

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