Regulation of the isofunctional genes ubiD and ubiX of the ubiquinone biosynthetic pathway of Escherichia coli

Haitao Zhang; G. T. Javor

doi:10.1016/S0378-1097(03)00343-4

Regulation of the isofunctional genes ubiD and ubiX of the ubiquinone biosynthetic pathway of Escherichia coli

Haitao Zhang, G. T. Javor

Biochemistry and Microbiology

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Abstract

The expressions of the isofunctional genes ubiD and ubiX of the ubiquinone biosynthetic pathway of Escherichia coli were compared under a variety of growth conditions and in several genetic backgrounds. LacZ operon fusions were constructed and were inserted in single copies into strain MC4100 and into its fnr, arcA or hemA carrying derivatives. During aerobic growth the expressions of both ubiD and ubiX depended on the carbon source: succinate>glycerol>glucose. Mutations in fnr, arcA or hemA increased the expressions of both genes. During anaerobic growth in LB medium glucose strongly inhibited the expression of ubiD but not of ubiX.

Original language	English
Pages (from-to)	67-72
Number of pages	6
Journal	FEMS Microbiology Letters
Volume	223
Issue number	1
DOIs	https://doi.org/10.1016/S0378-1097(03)00343-4
State	Published - Jun 6 2003

ASJC Scopus Subject Areas

Microbiology
Molecular Biology
Genetics

Keywords

Regulation
UbiD
UbiX

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Regulation of the isofunctional genes ubiD and ubiX of the ubiquinone biosynthetic pathway of Escherichia coli

Abstract

ASJC Scopus Subject Areas

Keywords

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