TY - JOUR
T1 - Recanalization, reperfusion, and recirculation in stroke
AU - Zhang, John H.
AU - Obenaus, Andre
AU - Liebeskind, David S.
AU - Tang, Jiping
AU - Hartman, Richard
AU - Pearce, William J.
N1 - Publisher Copyright:
© 2017, © The Author(s) 2017.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Recirculation, from arterial inflow routes through venous outflow pathways, was conceptualized in stroke research 50 years ago. As new technologies were developed, blocked arteries could be reopened, capillaries could be reperfused, and the use of recanalization and reperfusion grew to dominate therapeutic strategies. These approaches overwhelmingly focused on restoration of arterial and capillary inflow, but not on veins even though venous disorders may initiate or exacerbate brain injury. In this commentary, we advance the term “recirculation” after “recanalization” and “reperfusion” as a primary concept of stroke pathophysiology that targets the restoration of both the arterial and venous cerebral circulations.
AB - Recirculation, from arterial inflow routes through venous outflow pathways, was conceptualized in stroke research 50 years ago. As new technologies were developed, blocked arteries could be reopened, capillaries could be reperfused, and the use of recanalization and reperfusion grew to dominate therapeutic strategies. These approaches overwhelmingly focused on restoration of arterial and capillary inflow, but not on veins even though venous disorders may initiate or exacerbate brain injury. In this commentary, we advance the term “recirculation” after “recanalization” and “reperfusion” as a primary concept of stroke pathophysiology that targets the restoration of both the arterial and venous cerebral circulations.
KW - Recanalization
KW - recirculation
KW - reperfusion
KW - stroke pathophysiology
KW - stroke treatment
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U2 - 10.1177/0271678X17732695
DO - 10.1177/0271678X17732695
M3 - Comment/debate
C2 - 28925323
SN - 0271-678X
VL - 37
SP - 3818
EP - 3823
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 12
ER -