@inproceedings{38ef74d21184418da501fdb5a110d21c,
title = "Radiation exposure prior to ischemia decreases lesion volume, brain edema and cell death",
abstract = "Purpose: To investigate the neuronal response to ischemic injury following exposure to whole brain proton irradiation. Methods: Brain only proton irradiation (8 Gy, 250 MeV) was performed ten days prior to middle cerebral artery occlusion (MCAO) in 1 year old male Sprague Dawley rats. MCAO was induced in two animal groups: proton irradiated (MCAO + Rad) and MCAO only. Magnetic resonance imaging (MRI) and quantitative analysis were performed prior to and 2 days after irradiation, and then 2, 14 and 28 days after MCAO. After the last imaging time point animals were sacrificed and TUNEL staining was performed on 4% paraformaldehyde - fixed brain sections. Results: Neuroimaging demonstrated a reduction in ischemic lesion volume in the MCAO + Rad group compared with MCAO alone. Neurological deficits did not differ between ischemia groups. Interestingly, there was a 34% decrease in the number of TUNEL-positive cells in MCAO + Rad brains compared to MCAO alone. Conclusion: Our results suggest that radiation treatment reduces brain edema, ischemic lesion volume and peri-ischemic apoptosis. The underlying mechanisms are currently unknown and additional studies will elucidate the significance of these results.",
keywords = "Cerebral ischemia, MCAO, MRI, proton, radiation, stroke",
author = "E. Titova and A. Adami and R. Ostrowski and S. Lalas and R. Vlkolinsky and Zhang, {J. H.} and G. Nelson and A. Obenaus",
note = "Acta Neurochir Suppl. 2010;106:51-3. doi: 10.1007/978-3-211-98811-4_8.",
year = "2009",
doi = "10.1007/978-3-211-98811-4_8",
language = "English",
isbn = "9783211987582",
series = "Acta Neurochirurgica, Supplementum",
publisher = "Springer-Verlag Wien",
number = "106",
pages = "51--53",
booktitle = "Brain Edema XIV",
edition = "106",
}