Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse

Qing Xiong; Yan Jiao; Karen A. Hasty; S. Terry Canale; John M. Stuart; Wesley G. Beamer; Hong Wen Deng; David Baylink; Weikuan Gu

doi:10.1016/j.ygeno.2008.12.008

Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse

Qing Xiong, Yan Jiao, Karen A. Hasty, S. Terry Canale, John M. Stuart, Wesley G. Beamer, Hong Wen Deng, David Baylink, Weikuan Gu

Research output: Contribution to journal › Review article › peer-review

Abstract

This is an in silico analysis of data available from genome-wide scans. Through analysis of QTL, genes and polymorphisms that regulate BMD, we identified 82 BMD QTL, 191 BMD-associated (BMDA) genes, and 83 genes containing known BMD-associated polymorphisms (BMDAP). The catalogue of all BMDA/BMDAP genes and relevant literatures are provided. In total, there are substantially more BMDA/BMDAP genes in regions of the genome where QTL have been identified than in non-QTL regions. Among 191 BMDA genes and 83 BMDAP genes, 133 and 58 are localized in QTL regions, respectively. The difference was still noticeable for the chromosome distribution of these genes between QTL and non-QTL regions. These results have allowed us to generate an integrative profile of QTL, genes, polymorphisms that determine BMD. These data could facilitate more rapid and comprehensive identification of causal genes underlying the determination of BMD in mouse and provide new insights into how BMD is regulated in humans.

Original language	English
Pages (from-to)	401-414
Number of pages	14
Journal	Genomics
Volume	93
Issue number	5
DOIs	https://doi.org/10.1016/j.ygeno.2008.12.008
State	Published - May 2009

ASJC Scopus Subject Areas

Genetics

Keywords

BMD
Gene
Mouse
Polymorphism
QTL

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title = "Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse",

abstract = "This is an in silico analysis of data available from genome-wide scans. Through analysis of QTL, genes and polymorphisms that regulate BMD, we identified 82 BMD QTL, 191 BMD-associated (BMDA) genes, and 83 genes containing known BMD-associated polymorphisms (BMDAP). The catalogue of all BMDA/BMDAP genes and relevant literatures are provided. In total, there are substantially more BMDA/BMDAP genes in regions of the genome where QTL have been identified than in non-QTL regions. Among 191 BMDA genes and 83 BMDAP genes, 133 and 58 are localized in QTL regions, respectively. The difference was still noticeable for the chromosome distribution of these genes between QTL and non-QTL regions. These results have allowed us to generate an integrative profile of QTL, genes, polymorphisms that determine BMD. These data could facilitate more rapid and comprehensive identification of causal genes underlying the determination of BMD in mouse and provide new insights into how BMD is regulated in humans.",

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author = "Qing Xiong and Yan Jiao and Hasty, {Karen A.} and Canale, {S. Terry} and Stuart, {John M.} and Beamer, {Wesley G.} and Deng, {Hong Wen} and David Baylink and Weikuan Gu",

note = "We identified 191 BMDA genes within the whole mouse genome. Among them, 133 (approximately 70%) were located in regions know to contain QTL for BMD. The catalogue of all BMDA genes and relevant literature establishing their candidacy can be found in Supplemental Table 1.",

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AU - Xiong, Qing

AU - Jiao, Yan

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AU - Stuart, John M.

AU - Beamer, Wesley G.

AU - Deng, Hong Wen

AU - Baylink, David

AU - Gu, Weikuan

N1 - We identified 191 BMDA genes within the whole mouse genome. Among them, 133 (approximately 70%) were located in regions know to contain QTL for BMD. The catalogue of all BMDA genes and relevant literature establishing their candidacy can be found in Supplemental Table 1.

PY - 2009/5

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N2 - This is an in silico analysis of data available from genome-wide scans. Through analysis of QTL, genes and polymorphisms that regulate BMD, we identified 82 BMD QTL, 191 BMD-associated (BMDA) genes, and 83 genes containing known BMD-associated polymorphisms (BMDAP). The catalogue of all BMDA/BMDAP genes and relevant literatures are provided. In total, there are substantially more BMDA/BMDAP genes in regions of the genome where QTL have been identified than in non-QTL regions. Among 191 BMDA genes and 83 BMDAP genes, 133 and 58 are localized in QTL regions, respectively. The difference was still noticeable for the chromosome distribution of these genes between QTL and non-QTL regions. These results have allowed us to generate an integrative profile of QTL, genes, polymorphisms that determine BMD. These data could facilitate more rapid and comprehensive identification of causal genes underlying the determination of BMD in mouse and provide new insights into how BMD is regulated in humans.

AB - This is an in silico analysis of data available from genome-wide scans. Through analysis of QTL, genes and polymorphisms that regulate BMD, we identified 82 BMD QTL, 191 BMD-associated (BMDA) genes, and 83 genes containing known BMD-associated polymorphisms (BMDAP). The catalogue of all BMDA/BMDAP genes and relevant literatures are provided. In total, there are substantially more BMDA/BMDAP genes in regions of the genome where QTL have been identified than in non-QTL regions. Among 191 BMDA genes and 83 BMDAP genes, 133 and 58 are localized in QTL regions, respectively. The difference was still noticeable for the chromosome distribution of these genes between QTL and non-QTL regions. These results have allowed us to generate an integrative profile of QTL, genes, polymorphisms that determine BMD. These data could facilitate more rapid and comprehensive identification of causal genes underlying the determination of BMD in mouse and provide new insights into how BMD is regulated in humans.

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Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse

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ASJC Scopus Subject Areas

Keywords

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