TY - JOUR
T1 - Quantitative and qualitative fat analysis in human leg muscle of neuromuscular diseases by 1H MR spectroscopy in vivo
AU - Bárány, M.
AU - Venkatasubramanian, P. N.
AU - Mok, E.
AU - Siegel, I. M.
AU - Abraham, E.
AU - Wycliffe, N. D.
AU - Mafee, M. F.
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PY - 1989/5
Y1 - 1989/5
N2 - 1H MR spectra were recorded from human gastrocnemius muscle at 63.86 MHz using the body coil of the Signa scanner as transmitter and a 3‐in. surface coil as receiver. The fat content of the muscle was quantified relative to that of water in a selected volume or slice. The fat/water ratio was 0.05−0.07 for normal muscle but increased to 0.5−6.0 in primary and secondary muscular disorders such as Duchenne and myotonic dystrophy, Charcot‐Marie‐Tooth and polio muscular atrophy, cerebral palsy, and spina bifida. In Werdnig‐Hoffmann spinal atrophy the ratio was above 10. Water‐suppressed and sliceselective 1H spectroscopy was used for qualitative analysis of fat. The 1H profile of gastrocnemius muscles between healthy individuals and patients with neuromuscular diseases showed two major differences. In the normal muscle spectra, the resonance from the –(CH2)n– protons at 1.6 ppm was the most pronounced, whereas in the diseased muscle spectra resonances also appeared between 1.1 and 1.4 ppm. Some diseased muscle spectra showed multiple resonances from CHCH– in polyunsaturated fatty acids between 5.5 and 7.0 ppm. The corresponding resonances from CH‐CH2–, 1.9−2.0 ppm, and CH‐CH2‐CH, 2.7−2.9 ppm, were also seen. These peaks are usually not detected in normal muscle. © 1989 Academic Press, Inc.
AB - 1H MR spectra were recorded from human gastrocnemius muscle at 63.86 MHz using the body coil of the Signa scanner as transmitter and a 3‐in. surface coil as receiver. The fat content of the muscle was quantified relative to that of water in a selected volume or slice. The fat/water ratio was 0.05−0.07 for normal muscle but increased to 0.5−6.0 in primary and secondary muscular disorders such as Duchenne and myotonic dystrophy, Charcot‐Marie‐Tooth and polio muscular atrophy, cerebral palsy, and spina bifida. In Werdnig‐Hoffmann spinal atrophy the ratio was above 10. Water‐suppressed and sliceselective 1H spectroscopy was used for qualitative analysis of fat. The 1H profile of gastrocnemius muscles between healthy individuals and patients with neuromuscular diseases showed two major differences. In the normal muscle spectra, the resonance from the –(CH2)n– protons at 1.6 ppm was the most pronounced, whereas in the diseased muscle spectra resonances also appeared between 1.1 and 1.4 ppm. Some diseased muscle spectra showed multiple resonances from CHCH– in polyunsaturated fatty acids between 5.5 and 7.0 ppm. The corresponding resonances from CH‐CH2–, 1.9−2.0 ppm, and CH‐CH2‐CH, 2.7−2.9 ppm, were also seen. These peaks are usually not detected in normal muscle. © 1989 Academic Press, Inc.
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U2 - 10.1002/mrm.1910100206
DO - 10.1002/mrm.1910100206
M3 - Article
C2 - 2761380
SN - 0740-3194
VL - 10
SP - 210
EP - 226
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 2
ER -