Protection of minocycline on early brain injury after subarachnoid hemorrhage in rats

Zong Duo Guo; Hai Tao Wu; Xiao Chuan Sun; Xiao Dong Zhang; John H. Zhang

doi:10.1007/978-3-7091-0353-1_13

Protection of minocycline on early brain injury after subarachnoid hemorrhage in rats

Zong Duo Guo, Hai Tao Wu, Xiao Chuan Sun, Xiao Dong Zhang, John H. Zhang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Minocycline has been shown to be neuroprotective in cerebral ischemia and in other models of brain injury. Our goal is to observe the protection of minocycline on EBI after SAH and the mechanism. 48 adult male SD rats were randomly divided into four groups: the sham-operated group, SAH group, vehicle group (SAH + normal sodium), and minocycline group (SAH + minocycline). The SAH model was induced by injecting 300 μl of autologous arterial blood into the prechiasmatic cistern. Expressions of MMP-9 in the hippocampus were examined at 24 h by western blot and zymography. Western blot and zymography showed that the expression of total and active MMP-9 increased dramatically at 24 h after SAH compared with that of the sham group (P < 0.01). The clinical assessments got a lower score than that of the sham-operated group. After treated with minocycline, the expression of MMP-9 decreased significantly (P < 0.01 vs. vehicle group), and the clinical assessments improved. We conclude that minocycline can protect EBI after SAH, which may be related to the mechanism of inhibiting the expression of MMP-9 in the hippocampus.

Original language	English
Title of host publication	Early Brain Injury or Cerebral Vasospasm
Subtitle of host publication	Volume 1: Pathophysiology
Publisher	Springer-Verlag Wien
Pages	71-74
Number of pages	4
ISBN (Print)	9783709103524
DOIs	https://doi.org/10.1007/978-3-7091-0353-1_13
State	Published - 2011

Publication series

Name	Acta Neurochirurgica, Supplementum
Volume	110
ISSN (Print)	0065-1419
ISSN (Electronic)	0001-6268

ASJC Scopus Subject Areas

Surgery
Clinical Neurology

Keywords

Early brain injury
Matrix metalloproteinase 9
Minocycline
Subarachnoid hemorrhage

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Protection of minocycline on early brain injury after subarachnoid hemorrhage in rats. / Guo, Zong Duo; Wu, Hai Tao; Sun, Xiao Chuan et al.
Early Brain Injury or Cerebral Vasospasm: Volume 1: Pathophysiology. Springer-Verlag Wien, 2011. p. 71-74 (Acta Neurochirurgica, Supplementum; Vol. 110).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Protection of minocycline on early brain injury after subarachnoid hemorrhage in rats

Abstract

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ASJC Scopus Subject Areas

Keywords

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