TY - GEN
T1 - Post-treatment with SR49059 improves outcomes following an intracerebral hemorrhagic stroke in mice
AU - Manaenko, Anatol
AU - Fathali, Nancy
AU - Khatibi, Nikan H.
AU - Lekic, Tim
AU - Shum, Kenneth J.
AU - Martin, Robert
AU - Zhang, John H.
AU - Tang, Jiping
N1 - Funding Information:
Acknowledgement This study is partially supported by NIH NS053407 to J.H. Zhang and NS060936 to J. Tang. Conflict of interest statement
PY - 2011
Y1 - 2011
N2 - Intracerebral hemorrhage (ICH) is a devastating stroke subtype characterized by severe brain edema formation leading to cerebral blood flow compromise and parenchymal damage. Arginine vasopressin (AVP), a non-peptide antidiuretic hormone, has recently been implicated as a modulator of brain edema following injury. In this study, we investigated the effects of SR49059, a highly specific AVP V1a receptor antagonist, on brain injury outcomes following ICH, specifically assessing the ability of SR49059 in reducing brain edema and improving neurobehavioral deficits. Male CD1 mice (n = 35) were randomly assigned to the following groups: sham, ICH, ICH with SR49059 at 0.5 mg/kg, and ICH with SR49059 at 2 mg/kg. ICH was induced by using the collagenase injection model, and treatment was given 1 h after surgery. Post-assessment was conducted at 24 and 72 h after surgery, and included brain water content and neurobehavioral testing. The study found that SR49059 significantly reduced cerebral edema at 24 and 72 h post-ICH injury and improved neurobehavioral deficits at 72 h. Our study suggests that blockage of the AVP V1a receptor is a promising treatment target for improving ICH-induced brain injury. Further studies will be needed to confirm this relationship and determine future clinical direction.
AB - Intracerebral hemorrhage (ICH) is a devastating stroke subtype characterized by severe brain edema formation leading to cerebral blood flow compromise and parenchymal damage. Arginine vasopressin (AVP), a non-peptide antidiuretic hormone, has recently been implicated as a modulator of brain edema following injury. In this study, we investigated the effects of SR49059, a highly specific AVP V1a receptor antagonist, on brain injury outcomes following ICH, specifically assessing the ability of SR49059 in reducing brain edema and improving neurobehavioral deficits. Male CD1 mice (n = 35) were randomly assigned to the following groups: sham, ICH, ICH with SR49059 at 0.5 mg/kg, and ICH with SR49059 at 2 mg/kg. ICH was induced by using the collagenase injection model, and treatment was given 1 h after surgery. Post-assessment was conducted at 24 and 72 h after surgery, and included brain water content and neurobehavioral testing. The study found that SR49059 significantly reduced cerebral edema at 24 and 72 h post-ICH injury and improved neurobehavioral deficits at 72 h. Our study suggests that blockage of the AVP V1a receptor is a promising treatment target for improving ICH-induced brain injury. Further studies will be needed to confirm this relationship and determine future clinical direction.
KW - Arginine vasopressin (AVP)
KW - Intracerebral hemorrhage (ICH)
KW - SR49059
UR - http://www.scopus.com/inward/record.url?scp=79960662174&partnerID=8YFLogxK
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U2 - 10.1007/978-3-7091-0693-8_32
DO - 10.1007/978-3-7091-0693-8_32
M3 - Conference contribution
C2 - 21725754
SN - 9783709106921
T3 - Acta Neurochirurgica, Supplementum
SP - 191
EP - 196
BT - Intracerebral Hemorrhage Research
PB - Springer-Verlag Wien
ER -