TY - JOUR
T1 - Pathophysiology of Ganglioside GM1 in Ischemic Stroke
T2 - Ganglioside GM1: A Critical Review
AU - Zhang, Wenchao
AU - Krafft, Paul R.
AU - Wang, Tianlong
AU - Zhang, John H.
AU - Li, Li
AU - Tang, Jiping
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Ganglioside GM1 is a member of the ganglioside family which has been used in many countries and is thought of as a promising alternative treatment for preventing several neurological diseases, including cerebral ischemic injury. The therapeutic effects of GM1 have been proved both in neonates and in adults following ischemic brain damage; however, its clinical efficacy in patients with ischemic stroke is still uncertain. This review examines the recent knowledge of the neuroprotective properties of GM1 in ischemic stroke, collected in the past two decades. We conclude that GM1 may have potential for stroke treatment, although we need to be cautious in respect of its complications.
AB - Ganglioside GM1 is a member of the ganglioside family which has been used in many countries and is thought of as a promising alternative treatment for preventing several neurological diseases, including cerebral ischemic injury. The therapeutic effects of GM1 have been proved both in neonates and in adults following ischemic brain damage; however, its clinical efficacy in patients with ischemic stroke is still uncertain. This review examines the recent knowledge of the neuroprotective properties of GM1 in ischemic stroke, collected in the past two decades. We conclude that GM1 may have potential for stroke treatment, although we need to be cautious in respect of its complications.
KW - Ganglioside GM1
KW - monosialotetrahexosylganglioside
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=85070279874&partnerID=8YFLogxK
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U2 - 10.1177/0963689718822782
DO - 10.1177/0963689718822782
M3 - Review article
C2 - 30666888
SN - 0963-6897
VL - 28
SP - 657
EP - 661
JO - Cell Transplantation
JF - Cell Transplantation
IS - 6
ER -