TY - JOUR
T1 - Osteopontin as a candidate of therapeutic application for the acute brain injury
AU - Zhou, Yunxiang
AU - Yao, Yihan
AU - Sheng, Lesang
AU - Zhang, Jianmin
AU - Zhang, John H.
AU - Shao, Anwen
N1 - Publisher Copyright:
© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Acute brain injury is the leading cause of human death and disability worldwide, which includes intracerebral haemorrhage, subarachnoid haemorrhage, cerebral ischaemia, traumatic brain injury and hypoxia-ischaemia brain injury. Currently, clinical treatments for neurological dysfunction of acute brain injury have not been satisfactory. Osteopontin (OPN) is a complex adhesion protein and cytokine that interacts with multiple receptors including integrins and CD44 variants, exhibiting mostly neuroprotective roles and showing therapeutic potential for acute brain injury. OPN-induced tissue remodelling and functional repair mainly rely on its positive roles in the coordination of pro-inflammatory and anti-inflammatory responses, blood-brain barrier maintenance and anti-apoptotic actions, as well as other mechanisms such as affecting the chemotaxis and proliferation of nerve cells. The blood OPN strongly parallel with the OPN induced in the brain and can be used as a novel biomarker of the susceptibility, severity and outcome of acute brain injury. In the present review, we summarized the molecular signalling mechanisms of OPN as well as its overall role in different kinds of acute brain injury.
AB - Acute brain injury is the leading cause of human death and disability worldwide, which includes intracerebral haemorrhage, subarachnoid haemorrhage, cerebral ischaemia, traumatic brain injury and hypoxia-ischaemia brain injury. Currently, clinical treatments for neurological dysfunction of acute brain injury have not been satisfactory. Osteopontin (OPN) is a complex adhesion protein and cytokine that interacts with multiple receptors including integrins and CD44 variants, exhibiting mostly neuroprotective roles and showing therapeutic potential for acute brain injury. OPN-induced tissue remodelling and functional repair mainly rely on its positive roles in the coordination of pro-inflammatory and anti-inflammatory responses, blood-brain barrier maintenance and anti-apoptotic actions, as well as other mechanisms such as affecting the chemotaxis and proliferation of nerve cells. The blood OPN strongly parallel with the OPN induced in the brain and can be used as a novel biomarker of the susceptibility, severity and outcome of acute brain injury. In the present review, we summarized the molecular signalling mechanisms of OPN as well as its overall role in different kinds of acute brain injury.
KW - apoptosis
KW - intracerebral haemorrhage
KW - neuroprotection
KW - osteopontin
KW - stroke
KW - subarachnoid haemorrhage
KW - traumatic brain injury
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U2 - 10.1111/jcmm.15641
DO - 10.1111/jcmm.15641
M3 - Review article
C2 - 32657030
SN - 1582-1838
VL - 24
SP - 8918
EP - 8929
JO - Journal of Cellular and Molecular Medicine
JF - Journal of Cellular and Molecular Medicine
IS - 16
ER -