Abstract
To evaluate the potential link between nut intake and risk of type 2 diabetes in a North American cohort.
RESEARCH DESIGN AND METHODS
58,594 participants (64.7% female) from the Adventist Health Study 2 (AHS-2), a cohort study relating several lifestyle features with health outcomes, with an average age of 58years was longitudinally analyzed. This cohort included 2118 incident case of type 2 diabetes. Subjects’ total nut intake (tree nuts plus peanuts) was derived from the baseline food frequency questionnaire (validity correlation for nuts= 0.57). Logistic regression analysis was performed controlling for various relevant demographic and biological confounders.
RESULTS
Comparing high versus low intake of nuts (3 rd tertile versus 1 st tertile) in the multivariable adjusted model, participants with high nut intake had reduced risk of type 2 diabetes (OR 0.74, 95% CI 0.65, 0.85, p < 0.0001). Further adjustment for BMI attenuated this link and turned it non-significant. On stratification analysis by BMI, the nut intake-type 2 diabetes relation was significant among overweight/obese (BMI ≥ 25 kg/m 2 ) but not in lean subjects.
CONCLUSION
The present analysis suggests that long term high nut intake lowers type 2 diabetes risk, particularly among individuals with high BMI. These findings are consistent with those of other cohort and long term intervention studies.
| Original language | American English |
|---|---|
| State | Published - Apr 1 2016 |
Disciplines
- Biology
- Endocrinology, Diabetes, and Metabolism
- Internal Medicine
- Endocrinology