TY - GEN
T1 - Nut intake is inversely related to insulin resistance and CRP levels (370.2)
AU - EL-Amari, Salem
AU - Jaceldo-Siegl, Karen
AU - Rizzo, Nicolino
AU - Rajaram, Sujatha
AU - Dehom, Salem
AU - Sabaté, Joan
PY - 2014/4/1
Y1 - 2014/4/1
N2 - Objective: To examine the link between nuts intake and both insulin resistance (IR) and inflammation as measured by C- reactive protein (CRP). Methods: Data on 773 participants (571 females and 285 males), with a mean age of 58 years from the Adventist Health Study-2 cohort were Cross-sectionally analyzed. Total nuts intake, including peanuts was obtained from six unannounced telephone-based 24-hour dietary recalls and subjects were classified by tertiles of intake. IR was determined by Homeostasis Model Assessment (HOMA-IR), > 1.7. Multivariate logistic regression was used to compute the odds ratios (ORs) while adjusting for relevant demographic, dietary and lifestyle factors. Results: The odds of IR lowered with increased nuts intake. Compared with the lowest tertile the medium and high nut intake tertiles had an OR of 0.587 (95% CI 0.406-0. 847, P, 0.004) and an OR of 0.523 (95% CI 0.360-0.762, P, 0.001) respectively. This observed association was attenuated when additionally adjusting for BMI. High nut intake was linked to lower levels of CRP (OR 0.629, 95% CI 0.420-0.960, P, 0.014, comparing higher versus lower nut intake tertiles). However, further adjustment for BMI resulted in loss of the statistical significance. Conclusion: High nut intake favorably relates to insulin sensitivity and lower inflammatory status. BMI seems to modulate some of these effects.
AB - Objective: To examine the link between nuts intake and both insulin resistance (IR) and inflammation as measured by C- reactive protein (CRP). Methods: Data on 773 participants (571 females and 285 males), with a mean age of 58 years from the Adventist Health Study-2 cohort were Cross-sectionally analyzed. Total nuts intake, including peanuts was obtained from six unannounced telephone-based 24-hour dietary recalls and subjects were classified by tertiles of intake. IR was determined by Homeostasis Model Assessment (HOMA-IR), > 1.7. Multivariate logistic regression was used to compute the odds ratios (ORs) while adjusting for relevant demographic, dietary and lifestyle factors. Results: The odds of IR lowered with increased nuts intake. Compared with the lowest tertile the medium and high nut intake tertiles had an OR of 0.587 (95% CI 0.406-0. 847, P, 0.004) and an OR of 0.523 (95% CI 0.360-0.762, P, 0.001) respectively. This observed association was attenuated when additionally adjusting for BMI. High nut intake was linked to lower levels of CRP (OR 0.629, 95% CI 0.420-0.960, P, 0.014, comparing higher versus lower nut intake tertiles). However, further adjustment for BMI resulted in loss of the statistical significance. Conclusion: High nut intake favorably relates to insulin sensitivity and lower inflammatory status. BMI seems to modulate some of these effects.
UR - http://www.fasebj.org/content/28/1_Supplement/370.2?related-urls=yes;28/1_Supplement/370.2
M3 - Other contribution
ER -