Molecular hydrogen application in stroke: Bench to bedside

Lei Huang; Cameron Lenahan; Warren Boling; Jiping Tang; John H. Zhang

doi:10.2174/1381612826666200917152316

Molecular hydrogen application in stroke: Bench to bedside

Lei Huang, Cameron Lenahan, Warren Boling, Jiping Tang, John H. Zhang

Research output: Contribution to journal › Review article › peer-review

Abstract

Stroke is a major cause of mortality and morbidity worldwide. Effective treatments are limited. Molecular hydrogen is emerging as a novel medical gas with therapeutic potential for various neurological dis-eases, including stroke. We reviewed the experimental and clinical findings of the effects of molecular hydrogen therapy in stroke patients and models. The underlying neuroprotective mechanisms against stroke pathology were also discussed.

Original language	English
Pages (from-to)	703-712
Number of pages	10
Journal	Current Pharmaceutical Design
Volume	27
Issue number	5
DOIs	https://doi.org/10.2174/1381612826666200917152316
State	Published - 2021

ASJC Scopus Subject Areas

Pharmacology
Drug Discovery

Keywords

Antioxidant
Hydrogen gas
Hydrogen-rich saline
Hydrogen-rich water
Intracerebral hemorrhage
Ischemic stroke
Neuroprotection
Subarachnoid hemorrhage

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title = "Molecular hydrogen application in stroke: Bench to bedside",

abstract = "Stroke is a major cause of mortality and morbidity worldwide. Effective treatments are limited. Molecular hydrogen is emerging as a novel medical gas with therapeutic potential for various neurological dis-eases, including stroke. We reviewed the experimental and clinical findings of the effects of molecular hydrogen therapy in stroke patients and models. The underlying neuroprotective mechanisms against stroke pathology were also discussed.",

keywords = "Antioxidant, Hydrogen gas, Hydrogen-rich saline, Hydrogen-rich water, Intracerebral hemorrhage, Ischemic stroke, Neuroprotection, Subarachnoid hemorrhage",

author = "Lei Huang and Cameron Lenahan and Warren Boling and Jiping Tang and Zhang, {John H.}",

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volume = "27",

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T2 - Bench to bedside

AU - Huang, Lei

AU - Lenahan, Cameron

AU - Boling, Warren

AU - Tang, Jiping

AU - Zhang, John H.

PY - 2021

Y1 - 2021

N2 - Stroke is a major cause of mortality and morbidity worldwide. Effective treatments are limited. Molecular hydrogen is emerging as a novel medical gas with therapeutic potential for various neurological dis-eases, including stroke. We reviewed the experimental and clinical findings of the effects of molecular hydrogen therapy in stroke patients and models. The underlying neuroprotective mechanisms against stroke pathology were also discussed.

AB - Stroke is a major cause of mortality and morbidity worldwide. Effective treatments are limited. Molecular hydrogen is emerging as a novel medical gas with therapeutic potential for various neurological dis-eases, including stroke. We reviewed the experimental and clinical findings of the effects of molecular hydrogen therapy in stroke patients and models. The underlying neuroprotective mechanisms against stroke pathology were also discussed.

KW - Antioxidant

KW - Hydrogen gas

KW - Hydrogen-rich saline

KW - Hydrogen-rich water

KW - Intracerebral hemorrhage

KW - Ischemic stroke

KW - Neuroprotection

KW - Subarachnoid hemorrhage

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JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

IS - 5

ER -

Molecular hydrogen application in stroke: Bench to bedside

Abstract

ASJC Scopus Subject Areas

Keywords

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