TY - GEN
T1 - Mechanisms of early brain injury after SAH
T2 - Matrixmetalloproteinase 9
AU - Guo, Zong Duo
AU - Sun, Xiao Chuan
AU - Zhang, John H.
N1 - Part of the Acta Neurochirurgica Supplements book series (NEUROCHIRURGICA, volume 110/1) Subarachnoid hemorrhage (SAH) is an important cause of death and disability worldwide. To date, there is not a definitive treatment that completely prevents brain injury after SAH. Recently, early brain injury (EBI) has been pointed out to be the primary cause of mortality in SAH patients.
PY - 2011
Y1 - 2011
N2 - Subarachnoid hemorrhage (SAH) is an important cause of death and disability worldwide. To date, there is not a definitive treatment that completely prevents brain injury after SAH. Recently, early brain injury (EBI) has been pointed out to be the primary cause of mortality in SAH patients. Apoptosis that occurs in neuronal tissues and cerebral vasculature after SAH plays an essential role in EBI. Matrix metalloproteinase 9 (MMP-9) has been found to increase in many cerebral vascular diseases. There have been reports that MMP-9 can mediate apoptosis, which called anoikis in cerebral ischemia models, through cleaving main components of the extracellular matrix (ECM), especially laminin. Therefore, minocycline, which has been found to inhibit MMP-9, may be protective to brain injury after SAH. We based our hypothesis on the fact that SAH possesses some aspects that are similar to those of cerebral ischemia. It is conceivable that MMP-9 may also be involved in the pathological process of EBI after SAH, and minocycline can relieve anoikis and improve EBI after SAH.
AB - Subarachnoid hemorrhage (SAH) is an important cause of death and disability worldwide. To date, there is not a definitive treatment that completely prevents brain injury after SAH. Recently, early brain injury (EBI) has been pointed out to be the primary cause of mortality in SAH patients. Apoptosis that occurs in neuronal tissues and cerebral vasculature after SAH plays an essential role in EBI. Matrix metalloproteinase 9 (MMP-9) has been found to increase in many cerebral vascular diseases. There have been reports that MMP-9 can mediate apoptosis, which called anoikis in cerebral ischemia models, through cleaving main components of the extracellular matrix (ECM), especially laminin. Therefore, minocycline, which has been found to inhibit MMP-9, may be protective to brain injury after SAH. We based our hypothesis on the fact that SAH possesses some aspects that are similar to those of cerebral ischemia. It is conceivable that MMP-9 may also be involved in the pathological process of EBI after SAH, and minocycline can relieve anoikis and improve EBI after SAH.
KW - Early brain injury
KW - MMPs
KW - minocycline
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UR - http://www.scopus.com/inward/citedby.url?scp=85052610019&partnerID=8YFLogxK
U2 - 10.1007/978-3-7091-0353-1_11
DO - 10.1007/978-3-7091-0353-1_11
M3 - Conference contribution
C2 - 21116916
SN - 9783709103524
T3 - Acta Neurochirurgica, Supplementum
SP - 63
EP - 65
BT - Early Brain Injury or Cerebral Vasospasm
PB - Springer-Verlag Wien
ER -