@inproceedings{f11610e97bb7419e8aeb1825a25783a1,
title = "Matrix metalloproteinase 9 inhibition reduces early brain injury in cortex after subarachnoid hemorrhage",
abstract = "This study investigated the role of matrix metalloproteinase-9 (MMP-9) in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Sprague-Dawley male rats (n=30) between 250 and 300g were used. SAH was produced by injecting autologous arterial blood into the prechiasmatic cistern. SB-3CT, a selective MMP-9 inhibitor, was injected intraperitoneally after SAH induction. MMP-9 protein expression was measured by western blot; laminin expression and neuronal cells in the cerebral cortex were studied by immunohistochemistry and TUNEL staining at 24h after SAH. MMP-9 expression was increased after SAH and decreased by SB-3CT inhibition at 24h after SAH (P < 0.01). Laminin, the substrate of MMP-9, was decreased at 24h after SAH, and SB-3CT prevented laminin degradation. The number of TUNEL-positive neurons in cerebral cortex was increased after SAH and decreased by SB-3CT (P<0.01). MMP-9 may be involved in EBI after SAH and inhibition of MMP-9 may reduce EBI in cerebral cortex.",
keywords = "Cell death, Early brain injury, Matrix metalloproteinase-9, Subarachnoid hemorrhage",
author = "Guo, {Zong Duo} and Zhang, {Xiao Dong} and Wu, {Hai Tao} and Bin Lin and Sun, {Xiao Chuan} and Zhang, {John H.}",
note = "This study investigated the role of matrix metalloproteinase-9 (MMP-9) in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Sprague-Dawley male rats (n=30) between 250 and 300g were used.",
year = "2011",
doi = "10.1007/978-3-7091-0353-1_15",
language = "English",
isbn = "9783709103524",
series = "Acta Neurochirurgica, Supplementum",
publisher = "Springer-Verlag Wien",
pages = "81--84",
booktitle = "Early Brain Injury or Cerebral Vasospasm",
}