Male and Female Mice Exhibit Divergent Responses of the Cortical Vasculature to Traumatic Brain Injury

Amandine Jullienne; Arjang Salehi; Bethann M Affeldt; Mohsen Baghchechi; Elizabeth Haddad; Angela Avitua; Mark Walsworth; Isabelle Enhalric; Mary Hamer; Sonali Bhakta; Jiping Tang; John Zhang; William Pearce; Andrea Obenaus; William J Pearce

Male and Female Mice Exhibit Divergent Responses of the Cortical Vasculature to Traumatic Brain Injury

Amandine Jullienne, Arjang Salehi, Bethann M Affeldt, Mohsen Baghchechi, Elizabeth Haddad, Angela Avitua, Mark Walsworth, Isabelle Enhalric, Mary Hamer, Sonali Bhakta, Jiping Tang, John Zhang, William Pearce, Andrea Obenaus, William J Pearce

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Abstract

Traumatic brain injuries (TBI) occur in 1.7 million people each year in the USA. Little is known about how the cerebrovasculature is altered after TBI. We previously reported that TBI elicits acute decrements in cerebral vessels near the injury site in rats followed by revascularization over the subsequent 2 weeks. Sexual dimorphism of the brain is well documented and different hormonal levels in males and females differentially modify the recovery process after injury. However, the effects of biological sex on the temporal evolution of revascularization following TBI are understudied. Using a model of controlled cortical impact in male and female mice, we set out to determine if the injury and the repair process are affected by sex.

Original language	American English
Journal	Default journal
State	Published - 1800

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title = "Male and Female Mice Exhibit Divergent Responses of the Cortical Vasculature to Traumatic Brain Injury",

abstract = " Traumatic brain injuries (TBI) occur in 1.7 million people each year in the USA. Little is known about how the cerebrovasculature is altered after TBI. We previously reported that TBI elicits acute decrements in cerebral vessels near the injury site in rats followed by revascularization over the subsequent 2 weeks. Sexual dimorphism of the brain is well documented and different hormonal levels in males and females differentially modify the recovery process after injury. However, the effects of biological sex on the temporal evolution of revascularization following TBI are understudied. Using a model of controlled cortical impact in male and female mice, we set out to determine if the injury and the repair process are affected by sex.",

author = "Amandine Jullienne and Arjang Salehi and Affeldt, {Bethann M} and Mohsen Baghchechi and Elizabeth Haddad and Angela Avitua and Mark Walsworth and Isabelle Enhalric and Mary Hamer and Sonali Bhakta and Jiping Tang and John Zhang and William Pearce and Andrea Obenaus and Pearce, {William J}",

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T1 - Male and Female Mice Exhibit Divergent Responses of the Cortical Vasculature to Traumatic Brain Injury

AU - Jullienne, Amandine

AU - Salehi, Arjang

AU - Affeldt, Bethann M

AU - Baghchechi, Mohsen

AU - Haddad, Elizabeth

AU - Avitua, Angela

AU - Walsworth, Mark

AU - Enhalric, Isabelle

AU - Hamer, Mary

AU - Bhakta, Sonali

AU - Tang, Jiping

AU - Zhang, John

AU - Pearce, William

AU - Obenaus, Andrea

AU - Pearce, William J

PY - 1800

Y1 - 1800

N2 - Traumatic brain injuries (TBI) occur in 1.7 million people each year in the USA. Little is known about how the cerebrovasculature is altered after TBI. We previously reported that TBI elicits acute decrements in cerebral vessels near the injury site in rats followed by revascularization over the subsequent 2 weeks. Sexual dimorphism of the brain is well documented and different hormonal levels in males and females differentially modify the recovery process after injury. However, the effects of biological sex on the temporal evolution of revascularization following TBI are understudied. Using a model of controlled cortical impact in male and female mice, we set out to determine if the injury and the repair process are affected by sex.

AB - Traumatic brain injuries (TBI) occur in 1.7 million people each year in the USA. Little is known about how the cerebrovasculature is altered after TBI. We previously reported that TBI elicits acute decrements in cerebral vessels near the injury site in rats followed by revascularization over the subsequent 2 weeks. Sexual dimorphism of the brain is well documented and different hormonal levels in males and females differentially modify the recovery process after injury. However, the effects of biological sex on the temporal evolution of revascularization following TBI are understudied. Using a model of controlled cortical impact in male and female mice, we set out to determine if the injury and the repair process are affected by sex.

UR - https://scholarsrepository.llu.edu/llu-student-journal/vol3/iss1/13

M3 - Article

JO - Default journal

JF - Default journal

ER -

Male and Female Mice Exhibit Divergent Responses of the Cortical Vasculature to Traumatic Brain Injury

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