Magnetic resonance imaging in the canine double-haemorrhage subarachnoid haemorrhage model

T. Sugawara, A. Wang, V. Jadhav, T. Tsubokawa, A. Obenaus, John H. Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, we investigated T2 weighted imaging (T2WI) and T2 values of the cortex, thalamus and cerebrospinal fluid (CSF) of the ventricles in the canine double-haemorrhage subarachnoid haemorrhage (DHSAH) model. T2 values in the cortex increased compared to prescan values from 123.07 ± 18.72 msec on day 2 to 89.43 ± 1.98 msec on day 7 (p < 0.05). A trend toward a temporal increase in T2 values was observed in the thalamus, but did not reach significance. The T2 values of the ventricular CSF increased by 102.2% on day 2 and 159.6% on day 7 compared to prescan values. These changes reached significance (p < 0.05) on day 7. Additionally, the ventricular size increased over the study period. Our data suggest that we can use this model to investigate acute brain injury and normal pressure hydrocephalus (NPH) after SAH.

Original languageEnglish
Title of host publicationCerebral Vasospasm
Subtitle of host publicationNew Strategies in Research and Treatment
PublisherSpringer-Verlag Wien
Pages235-239
Number of pages5
Edition104
ISBN (Print)9783211757178
DOIs
StatePublished - 2008

Publication series

NameActa Neurochirurgica, Supplementum
Number104
ISSN (Print)0065-1419

ASJC Scopus Subject Areas

  • Surgery
  • Clinical Neurology

Keywords

  • MRI
  • SAH
  • T2 weighted imaging
  • acute brain injury
  • double-haemorrhage subarachnoid haemorrhage model
  • edema
  • normal pressure hydrocephalus

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