TY - JOUR
T1 - Localization and upregulation of survivin in cancer health disparities
T2 - A clinical perspective
AU - Khan, Salma
AU - Bennit, Heather Ferguson
AU - Asuncion Valenzuela, Malyn May
AU - Turay, David
AU - Osterman, Carlos J.Diaz
AU - Moyron, Ron B.
AU - Esebanmen, Grace E.
AU - Ashok, Arjun
AU - Wall, Nathan R.
N1 - Publisher Copyright:
© 2015 Khan et al.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Survivin is one of the most important members of the inhibitors of apoptosis protein family, as it is expressed in most human cancers but is absent in normal, differentiated tissues. Lending to its importance, survivin has proven associations with apoptosis and cell cycle control, and has more recently been shown to modulate the tumor microenvironment and immune evasion as a result of its extracellular localization. Upregulation of survivin has been found in many cancers including breast, prostate, pancreatic, and hematological malignancies, and it may prove to be associated with the advanced presentation, poorer prognosis, and lower survival rates observed in ethnically diverse populations.
AB - Survivin is one of the most important members of the inhibitors of apoptosis protein family, as it is expressed in most human cancers but is absent in normal, differentiated tissues. Lending to its importance, survivin has proven associations with apoptosis and cell cycle control, and has more recently been shown to modulate the tumor microenvironment and immune evasion as a result of its extracellular localization. Upregulation of survivin has been found in many cancers including breast, prostate, pancreatic, and hematological malignancies, and it may prove to be associated with the advanced presentation, poorer prognosis, and lower survival rates observed in ethnically diverse populations.
KW - Cancer
KW - Exosomes
KW - Health disparity
KW - Survivin
UR - http://www.scopus.com/inward/record.url?scp=84982299343&partnerID=8YFLogxK
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U2 - 10.2147/BTT.S83864
DO - 10.2147/BTT.S83864
M3 - Review article
SN - 1177-5475
VL - 9
SP - 57
EP - 67
JO - Biologics: Targets and Therapy
JF - Biologics: Targets and Therapy
ER -