TY - JOUR
T1 - Interleukin 24
T2 - Mechanisms and therapeutic potential of an anti-cancer gene
AU - Whitaker, Erin L.
AU - Filippov, Valery A.
AU - Duerksen-Hughes, Penelope J.
N1 - Interleukin 24 (mda-7/IL-24) has been classified as an anti-cancer gene for its ability to selectively induce cell death in cancer cells while having little to no effect on normal cells. Although the exact mechanisms by which IL-24 functions have not been completely elucidated, several pathways have ...
PY - 2012/12
Y1 - 2012/12
N2 - Interleukin 24 (mda-7/IL-24) has been classified as an anti-cancer gene for its ability to selectively induce cell death in cancer cells while having little to no effect on normal cells. Although the exact mechanisms by which IL-24 functions have not been completely elucidated, several pathways have consistently been identified: endoplasmic reticulum stress, ceramide-mediated events, and the generation of reactive oxygen species. In addition to these mechanistic analyses, significant progress has also been reported regarding the clinical potential of this anti-cancer gene. For example, many groups are utilizing mda-7/IL-24 in combination with other cancer therapies. This review examines the current research and potential future of this important anti-cancer gene.
AB - Interleukin 24 (mda-7/IL-24) has been classified as an anti-cancer gene for its ability to selectively induce cell death in cancer cells while having little to no effect on normal cells. Although the exact mechanisms by which IL-24 functions have not been completely elucidated, several pathways have consistently been identified: endoplasmic reticulum stress, ceramide-mediated events, and the generation of reactive oxygen species. In addition to these mechanistic analyses, significant progress has also been reported regarding the clinical potential of this anti-cancer gene. For example, many groups are utilizing mda-7/IL-24 in combination with other cancer therapies. This review examines the current research and potential future of this important anti-cancer gene.
KW - Anti-cancer gene
KW - Apoptosis
KW - IL-24
KW - Mda-7
KW - Mechanism
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U2 - 10.1016/j.cytogfr.2012.08.004
DO - 10.1016/j.cytogfr.2012.08.004
M3 - Short survey
C2 - 22981288
SN - 1359-6101
VL - 23
SP - 323
EP - 331
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
IS - 6
ER -