TY - JOUR
T1 - Improvements in human health through production of human milk proteins in transgenic food plants
AU - Arakawa, T.
AU - Chong, D. K.X.
AU - Slattery, C. W.
AU - Langridge, W. H.R.
N1 - Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 464) Plants are particularly suitable bioreactors for the production of proteins, as their eu-karyotic nature frequently directs the appropriate post-translational modifications of recombinant proteins to retain native biological activity.
PY - 1999
Y1 - 1999
N2 - Plants are particularly suitable bioreactors for the production of proteins, as their eukaryotic nature frequently directs the appropriate post-translational modifications of recombinant proteins to retain native biological activity. The autotrophic growth of plants makes this in vivo biosynthesis system economically competitive for supplementation or replacement of conventional production systems in the future. For the production of biologically active proteins, food plants provide the advantage of direct delivery via consumption of transformed plant tissues. Here we describe the production of recombinant human milk proteins in food plants for improvements in human nutrition and health, with emphasis on enhanced nutrition for non-breast fed infants as well as children and adults. Nutritional improvements in edible plants generated through advancements in recombinant DNA technology are rapidly repositioning the world for enjoyment of a more healthful diet for humans in all age groups.
AB - Plants are particularly suitable bioreactors for the production of proteins, as their eukaryotic nature frequently directs the appropriate post-translational modifications of recombinant proteins to retain native biological activity. The autotrophic growth of plants makes this in vivo biosynthesis system economically competitive for supplementation or replacement of conventional production systems in the future. For the production of biologically active proteins, food plants provide the advantage of direct delivery via consumption of transformed plant tissues. Here we describe the production of recombinant human milk proteins in food plants for improvements in human nutrition and health, with emphasis on enhanced nutrition for non-breast fed infants as well as children and adults. Nutritional improvements in edible plants generated through advancements in recombinant DNA technology are rapidly repositioning the world for enjoyment of a more healthful diet for humans in all age groups.
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U2 - 10.1007/978-1-4615-4729-7_12
DO - 10.1007/978-1-4615-4729-7_12
M3 - Article
C2 - 10335392
SN - 0065-2598
VL - 464
SP - 149
EP - 159
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -