TY - JOUR
T1 - Hypoxic-ischemic injury
T2 - Utility of susceptibility-weighted imaging
AU - Kitamura, Gene
AU - Kido, Daniel
AU - Wycliffe, Nathaniel
AU - Jacobson, J. Paul
AU - Oyoyo, Udochukwu
AU - Ashwal, Stephen
N1 - Pediatr Neurol. 2011 Oct;45(4):220-4. doi: 10.1016/j.pediatrneurol.2011.06.009.
PY - 2011/10
Y1 - 2011/10
N2 - Magnetic resonance imaging is increasingly used to assess neonatal hypoxic-ischemic injury, and several scoring systems were developed to predict neurologic outcomes in these patients. We examined the magnetic resonance imaging studies of 33 neonates/infants who manifested acute perinatal hypoxic-ischemic injuries. Using a seven-point susceptibility-weighted imaging categorical grading scale, each patient received a "prominence of vein" score, which was dichotomized into a "normal" or "abnormal" group. Six-month outcomes were assessed using the Pediatric Cerebral Performance Category Scale. We then determined whether "prominence of vein" scores correlated with neurologic outcomes in patients with hypoxic-ischemic injuries, and compared these results with the Barkovich magnetic resonance imaging scoring system. Patients with "normal" "prominence of vein" scores demonstrated better outcomes (mean Pediatric Cerebral Performance Category Scale value = 2) than patients with "abnormal" "prominence of vein" scores (mean Pediatric Cerebral Performance Category Scale value = 4). The dichotomized "prominence of vein" groups demonstrated correlations with the Barkovich magnetic resonance imaging scores of the proton density-weighted basal ganglia, watershed, and combined basal ganglia/watershed regions. The susceptibility-weighted imaging categorical grading scale may aid in predicting neurologic outcomes after hypoxic-ischemic injuries.
AB - Magnetic resonance imaging is increasingly used to assess neonatal hypoxic-ischemic injury, and several scoring systems were developed to predict neurologic outcomes in these patients. We examined the magnetic resonance imaging studies of 33 neonates/infants who manifested acute perinatal hypoxic-ischemic injuries. Using a seven-point susceptibility-weighted imaging categorical grading scale, each patient received a "prominence of vein" score, which was dichotomized into a "normal" or "abnormal" group. Six-month outcomes were assessed using the Pediatric Cerebral Performance Category Scale. We then determined whether "prominence of vein" scores correlated with neurologic outcomes in patients with hypoxic-ischemic injuries, and compared these results with the Barkovich magnetic resonance imaging scoring system. Patients with "normal" "prominence of vein" scores demonstrated better outcomes (mean Pediatric Cerebral Performance Category Scale value = 2) than patients with "abnormal" "prominence of vein" scores (mean Pediatric Cerebral Performance Category Scale value = 4). The dichotomized "prominence of vein" groups demonstrated correlations with the Barkovich magnetic resonance imaging scores of the proton density-weighted basal ganglia, watershed, and combined basal ganglia/watershed regions. The susceptibility-weighted imaging categorical grading scale may aid in predicting neurologic outcomes after hypoxic-ischemic injuries.
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U2 - 10.1016/j.pediatrneurol.2011.06.009
DO - 10.1016/j.pediatrneurol.2011.06.009
M3 - Article
C2 - 21907881
SN - 0887-8994
VL - 45
SP - 220
EP - 224
JO - Pediatric Neurology
JF - Pediatric Neurology
IS - 4
ER -