Generation of mesenchymal stem cells by blood cell reprogramming

Wanqiu Chen; David J. Baylink; K. H.William Lau; Xiao Bing Zhang

doi:10.2174/1574888X10666150531173448

Generation of mesenchymal stem cells by blood cell reprogramming

Wanqiu Chen, David J. Baylink, K. H.William Lau, Xiao Bing Zhang

Research output: Contribution to journal › Review article › peer-review

Abstract

Mesenchymal stem cells (MSCs) have been successfully used to treat multiple diseases in animal studies and clinical trials. Currently, the commonly used MSCs are derived from bone marrow and adipose tissue. Alternative approaches include differentiation of induced pluripotent stem cells (iPSCs) into MSCs, or direct reprogramming of blood cells into MSCs. This review summarizes recent progresses concerning how to generate MSCs by blood cell reprogramming and how studies in cellular reprogramming may help identify new factors to expand or even rejuvenate adult MSCs.

Original language	English
Pages (from-to)	114-121
Number of pages	8
Journal	Current Stem Cell Research and Therapy
Volume	11
Issue number	2
DOIs	https://doi.org/10.2174/1574888X10666150531173448
State	Published - Jan 1 2016

ASJC Scopus Subject Areas

Medicine (miscellaneous)

Keywords

Blood
Hematopoietic cells
Induced pluripotent stem cells
Mesenchymal stem cells
Reprogramming

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abstract = "Mesenchymal stem cells (MSCs) have been successfully used to treat multiple diseases in animal studies and clinical trials. Currently, the commonly used MSCs are derived from bone marrow and adipose tissue. Alternative approaches include differentiation of induced pluripotent stem cells (iPSCs) into MSCs, or direct reprogramming of blood cells into MSCs. This review summarizes recent progresses concerning how to generate MSCs by blood cell reprogramming and how studies in cellular reprogramming may help identify new factors to expand or even rejuvenate adult MSCs.",

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AU - Baylink, David J.

AU - Lau, K. H.William

AU - Zhang, Xiao Bing

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AB - Mesenchymal stem cells (MSCs) have been successfully used to treat multiple diseases in animal studies and clinical trials. Currently, the commonly used MSCs are derived from bone marrow and adipose tissue. Alternative approaches include differentiation of induced pluripotent stem cells (iPSCs) into MSCs, or direct reprogramming of blood cells into MSCs. This review summarizes recent progresses concerning how to generate MSCs by blood cell reprogramming and how studies in cellular reprogramming may help identify new factors to expand or even rejuvenate adult MSCs.

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KW - Induced pluripotent stem cells

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KW - Reprogramming

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Generation of mesenchymal stem cells by blood cell reprogramming

Abstract

ASJC Scopus Subject Areas

Keywords

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