Ferrosenescence: The iron age of neurodegeneration?

Adonis Sfera; Kelsey Bullock; Amy Price; Luzmin Inderias; Carolina Osorio

doi:10.1016/j.mad.2017.11.012

Ferrosenescence: The iron age of neurodegeneration?

Adonis Sfera, Kelsey Bullock, Amy Price, Luzmin Inderias, Carolina Osorio

Research output: Contribution to journal › Review article › peer-review

Abstract

Aging has been associated with iron retention in many cell types, including the neurons, promoting neurodegeneration by ferroptosis. Excess intracellular iron accelerates aging by damaging the DNA and blocking genomic repair systems, a process we define as ferrosenescence. Novel neuroimaging and proteomic techniques have pinpointed indicators of both iron retention and ferrosenescence, allowing for their early correction, potentially bringing prevention of neurodegenerative disorders within reach. In this review, we take a closer look at the early markers of iron dyshomeostasis in neurodegenerative disorders, focusing on preventive strategies based on nutritional and microbiome manipulations.

Original language	English
Pages (from-to)	63-75
Number of pages	13
Journal	Mechanisms of Ageing and Development
Volume	174
DOIs	https://doi.org/10.1016/j.mad.2017.11.012
State	Published - Sep 2018

ASJC Scopus Subject Areas

Aging
Developmental Biology

Keywords

Antioxidants
BACE-1
Cancer
Cognitive impairment
DNA damage
Ferroportin
Ferroptosis
Frontotemporal dementia
Gluthatione perocidase
Insulin-like growth factor
Iron
Iron regulatory protein-2
Mitochomdria associated membranes
Mitochondrial DNA
Quantitative susceptibility mapping
Selenium
Transferrin
Transposable elements
p53

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title = "Ferrosenescence: The iron age of neurodegeneration?",

abstract = "Aging has been associated with iron retention in many cell types, including the neurons, promoting neurodegeneration by ferroptosis. Excess intracellular iron accelerates aging by damaging the DNA and blocking genomic repair systems, a process we define as ferrosenescence. Novel neuroimaging and proteomic techniques have pinpointed indicators of both iron retention and ferrosenescence, allowing for their early correction, potentially bringing prevention of neurodegenerative disorders within reach. In this review, we take a closer look at the early markers of iron dyshomeostasis in neurodegenerative disorders, focusing on preventive strategies based on nutritional and microbiome manipulations.",

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author = "Adonis Sfera and Kelsey Bullock and Amy Price and Luzmin Inderias and Carolina Osorio",

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year = "2018",

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T2 - The iron age of neurodegeneration?

AU - Sfera, Adonis

AU - Bullock, Kelsey

AU - Price, Amy

AU - Inderias, Luzmin

AU - Osorio, Carolina

PY - 2018/9

Y1 - 2018/9

N2 - Aging has been associated with iron retention in many cell types, including the neurons, promoting neurodegeneration by ferroptosis. Excess intracellular iron accelerates aging by damaging the DNA and blocking genomic repair systems, a process we define as ferrosenescence. Novel neuroimaging and proteomic techniques have pinpointed indicators of both iron retention and ferrosenescence, allowing for their early correction, potentially bringing prevention of neurodegenerative disorders within reach. In this review, we take a closer look at the early markers of iron dyshomeostasis in neurodegenerative disorders, focusing on preventive strategies based on nutritional and microbiome manipulations.

AB - Aging has been associated with iron retention in many cell types, including the neurons, promoting neurodegeneration by ferroptosis. Excess intracellular iron accelerates aging by damaging the DNA and blocking genomic repair systems, a process we define as ferrosenescence. Novel neuroimaging and proteomic techniques have pinpointed indicators of both iron retention and ferrosenescence, allowing for their early correction, potentially bringing prevention of neurodegenerative disorders within reach. In this review, we take a closer look at the early markers of iron dyshomeostasis in neurodegenerative disorders, focusing on preventive strategies based on nutritional and microbiome manipulations.

KW - Antioxidants

KW - BACE-1

KW - Cancer

KW - Cognitive impairment

KW - DNA damage

KW - Ferroportin

KW - Ferroptosis

KW - Frontotemporal dementia

KW - Gluthatione perocidase

KW - Insulin-like growth factor

KW - Iron

KW - Iron regulatory protein-2

KW - Mitochomdria associated membranes

KW - Mitochondrial DNA

KW - Quantitative susceptibility mapping

KW - Selenium

KW - Transferrin

KW - Transposable elements

KW - p53

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JO - Mechanisms of Ageing and Development

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ER -

Ferrosenescence: The iron age of neurodegeneration?

Abstract

ASJC Scopus Subject Areas

Keywords

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