TY - JOUR
T1 - Epigenetic interventions for brain rejuvenation
T2 - Anchoring age-related transposons
AU - Sfera, Adonis
AU - Fayard, Lisa
AU - Osorio, Carolina
AU - Price, Amy
N1 - 1. Iron and homocysteine accumulation in aging neurons alter genomic methylation. 2. The altered methylome reactivates neuronal cell cycle, enabling transposable element mobilization. 3. miR29/p53 axis restores age-related methylation shifts, reactivating neuronal plasticity. 4. Augmentation of miR-29/p53 axis may preempt neurodegenerative disorders. Epigenetics refers to the inheritable, non-DNA-related changes in gene expression.
PY - 2018/4
Y1 - 2018/4
UR - http://www.scopus.com/inward/record.url?scp=85048334989&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048334989&partnerID=8YFLogxK
U2 - 10.4103/1673-5374.230283
DO - 10.4103/1673-5374.230283
M3 - Review article
SN - 1673-5374
VL - 13
SP - 635
EP - 636
JO - Neural Regeneration Research
JF - Neural Regeneration Research
IS - 4
ER -