Effects of early serum glucose levels on prognosis of patients with acute intracerebral hemorrhage

Studies have indicated that hyperglycemia might cause cerebral damage to patients after acute intracerebral hemorrhage (ICH). But systematic studies on the effects of diabetes, stress hyperglycemia and normal serum glucose level on the prognosis of ICH patients are insufficient. It is essential to explore the prognosis among them. According to their serum glucose level within 24 h, 189 patients with ICH were divided into three groups: diabetes (group A), stress hyperglycemia (group B) and normal serum glucose (group C). The activity of daily living ability of patients was evaluated by Barthel index at 30 days after admission. The data analysis was done using cumulative logit model and rank sum test. Significant differences were observed in prognosis between group A and group C (OR: 0.056; CI: 0.022-0.143; p < 0.0001), B and C (OR: 0.081; CI: 0.039-0.167; p < 0.0001), respectively; there was no significant difference between A and B (p > 0.05). No difference was found between A and B in the early serum glucose level, but significant differences were observed between A and C, and between B and C. Early hyperglycemia may worsen the prognosis of ICH patients, though patients with diabetes or stress hyperglycemia after ICH may have similar outcomes when early serum glucose levels fluctuate within the same range.