TY - JOUR
T1 - Diesel exhaust exposure, its multi-system effects, and the effect of new technology diesel exhaust
AU - Reis, Haley
AU - Reis, Cesar
AU - Sharip, Akbar
AU - Reis, Wenes
AU - Zhao, Yong
AU - Sinclair, Ryan
AU - Beeson, Lawrence
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/5
Y1 - 2018/5
N2 - Exposure to diesel exhaust (DE) from vehicles and industry is hazardous and affects proper function of organ systems. DE can interfere with normal physiology after acute and chronic exposure to particulate matter (PM). Exposure leads to potential systemic disease processes in the central nervous, visual, hematopoietic, respiratory, cardiovascular, and renal systems. In this review, we give an overview of the epidemiological evidence supporting the harmful effects of diesel exhaust, and the numerous animal studies conducted to investigate the specific pathophysiological mechanisms behind DE exposure. Additionally, this review includes a summary of studies that used biomarkers as an indication of biological plausibility, and also studies evaluating new technology diesel exhaust (NTDE) and its systemic effects. Lastly, this review includes new approaches to improving DE emissions, and emphasizes the importance of ongoing study in this field of environmental health.
AB - Exposure to diesel exhaust (DE) from vehicles and industry is hazardous and affects proper function of organ systems. DE can interfere with normal physiology after acute and chronic exposure to particulate matter (PM). Exposure leads to potential systemic disease processes in the central nervous, visual, hematopoietic, respiratory, cardiovascular, and renal systems. In this review, we give an overview of the epidemiological evidence supporting the harmful effects of diesel exhaust, and the numerous animal studies conducted to investigate the specific pathophysiological mechanisms behind DE exposure. Additionally, this review includes a summary of studies that used biomarkers as an indication of biological plausibility, and also studies evaluating new technology diesel exhaust (NTDE) and its systemic effects. Lastly, this review includes new approaches to improving DE emissions, and emphasizes the importance of ongoing study in this field of environmental health.
KW - Air pollution
KW - Cardiovascular
KW - Central nervous system
KW - Diesel exhaust
KW - Diesel exhaust particles
KW - Eyes
KW - Hematopoietic
KW - Kidney
KW - New technology diesel exhaust
KW - Respiratory
UR - http://www.scopus.com/inward/record.url?scp=85042928379&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042928379&partnerID=8YFLogxK
U2 - 10.1016/j.envint.2018.02.042
DO - 10.1016/j.envint.2018.02.042
M3 - Review article
C2 - 29524921
SN - 0160-4120
VL - 114
SP - 252
EP - 265
JO - Environment International
JF - Environment International
ER -