Contusion Rodent Model of Traumatic Brain Injury: Controlled Cortical Impact

Marie Line Fournier, Tifenn Clément, Justine Aussudre, Nikolaus Plesnila, André Obenaus, Jérôme Badaut

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Traumatic brain injury (TBI) is a heterogeneous brain injury which represents one of the leading causes of mortality and disability worldwide. Rodent TBI models are helpful to examine the cellular and molecular mechanisms after injury. Controlled cortical impact (CCI) is one of the most commonly used TBI models in rats and mice, based on its consistency of injury and ease of implementation. Here, we describe a CCI protocol to induce a moderate contusion to the somatosensory motor cortex. We provide additional protocols for monitoring animals after CCI induction.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages49-65
Number of pages17
DOIs
StatePublished - 2021

Publication series

NameMethods in Molecular Biology
Volume2193
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

ASJC Scopus Subject Areas

  • Molecular Biology
  • Genetics

Keywords

  • Behavior
  • Immunohistochemistry
  • MRI
  • Pediatric
  • Traumatic brain injury

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