TY - JOUR
T1 - Contact dermatitis and atopic dermatitis
T2 - two tales, an interwoven story
AU - Holmes, G. Alden
AU - Vassantachart, Janna M.
AU - Sung, Calvin T.
AU - Goldenberg, Alina
AU - Jacob, Sharon E.
N1 - Atopic dermatitis is a multifactorial disease that can concomitantly occur with irritant or allergic contact dermatitis. The colloquial use of atopic dermatitis and eczema interchangeably has created confusion among patients and providers alike. Atopic skin is a complex entity that involves a defect ...
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Atopic dermatitis is a multifactorial disease that can concomitantly occur with irritant or allergic contact dermatitis. The colloquial use of atopic dermatitis and eczema interchangeably has created confusion among patients and providers alike. Atopic skin is a complex entity that involves a defective barrier and biome, an aberrant immune response, and abnormal neural activation, while eczema is a generalized term denoting a particular appearance common to multiple diagnoses including atopic dermatitis and contact dermatitis. The conventional paradigm that simplifies atopic dermatitis and allergic contact dermatitis into distinct Th2 and Th1 processes, respectively, fails to acknowledge potential immunologic intersection points and contributes to impaired disease management. This article will review the complex interplay of atopic dermatitis and contact dermatitis and discuss treatment strategies for recalcitrant cases.
AB - Atopic dermatitis is a multifactorial disease that can concomitantly occur with irritant or allergic contact dermatitis. The colloquial use of atopic dermatitis and eczema interchangeably has created confusion among patients and providers alike. Atopic skin is a complex entity that involves a defective barrier and biome, an aberrant immune response, and abnormal neural activation, while eczema is a generalized term denoting a particular appearance common to multiple diagnoses including atopic dermatitis and contact dermatitis. The conventional paradigm that simplifies atopic dermatitis and allergic contact dermatitis into distinct Th2 and Th1 processes, respectively, fails to acknowledge potential immunologic intersection points and contributes to impaired disease management. This article will review the complex interplay of atopic dermatitis and contact dermatitis and discuss treatment strategies for recalcitrant cases.
UR - http://www.scopus.com/inward/record.url?scp=85069221349&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069221349&partnerID=8YFLogxK
U2 - 10.23736/S0392-0488.18.06236-3
DO - 10.23736/S0392-0488.18.06236-3
M3 - Review article
C2 - 30428660
SN - 0392-0488
VL - 154
SP - 425
EP - 434
JO - Giornale Italiano di Dermatologia e Venereologia
JF - Giornale Italiano di Dermatologia e Venereologia
IS - 4
ER -