TY - JOUR
T1 - Chronic cerebrovascular dysfunction after traumatic brain injury
AU - Jullienne, Amandine
AU - Obenaus, Andre
AU - Ichkova, Aleksandra
AU - Savona-Baron, Catherine
AU - Pearce, William J.
AU - Badaut, Jerome
N1 - Publisher Copyright:
© 2016 Wiley Periodicals, Inc.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Traumatic brain injuries (TBI) often involve vascular dysfunction that leads to long-term alterations in physiological and cognitive functions of the brain. Indeed, all the cells that form blood vessels and that are involved in maintaining their proper function can be altered by TBI. This Review focuses on the different types of cerebrovascular dysfunction that occur after TBI, including cerebral blood flow alterations, autoregulation impairments, subarachnoid hemorrhage, vasospasms, blood-brain barrier disruption, and edema formation. We also discuss the mechanisms that mediate these dysfunctions, focusing on the cellular components of cerebral blood vessels (endothelial cells, smooth muscle cells, astrocytes, pericytes, perivascular nerves) and their known and potential roles in the secondary injury cascade.
AB - Traumatic brain injuries (TBI) often involve vascular dysfunction that leads to long-term alterations in physiological and cognitive functions of the brain. Indeed, all the cells that form blood vessels and that are involved in maintaining their proper function can be altered by TBI. This Review focuses on the different types of cerebrovascular dysfunction that occur after TBI, including cerebral blood flow alterations, autoregulation impairments, subarachnoid hemorrhage, vasospasms, blood-brain barrier disruption, and edema formation. We also discuss the mechanisms that mediate these dysfunctions, focusing on the cellular components of cerebral blood vessels (endothelial cells, smooth muscle cells, astrocytes, pericytes, perivascular nerves) and their known and potential roles in the secondary injury cascade.
KW - Cerebrovascular dysfunction
KW - Neurovascular dysfunction
KW - Traumatic brain injury
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U2 - 10.1002/jnr.23732
DO - 10.1002/jnr.23732
M3 - Review article
C2 - 27117494
SN - 0360-4012
VL - 94
SP - 609
EP - 622
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
IS - 7
ER -