Capsaicin Pre-treatment Provides Neurovascular Protection Against Neonatal Hypoxic-Ischemic Brain Injury in Rats

Nikan H. Khatibi; Vikram Jadhav; Shelton Charles; Jeffrey Chiu; John Buchholz; Jiping Tang; John H. Zhang

doi:10.1007/978-3-7091-0693-8_38

Capsaicin Pre-treatment Provides Neurovascular Protection Against Neonatal Hypoxic-Ischemic Brain Injury in Rats

Nikan H. Khatibi, Vikram Jadhav, Shelton Charles, Jeffrey Chiu, John Buchholz, Jiping Tang, John H. Zhang

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has recently been shown to provide neuroprotection against brain injury in experimental adult models of cerebral ischemia. Accordingly, in this study, we investigated the way in which capsaicin-mediated TRPV1 modulation could attenuate damage in an experimental hypoxic-ischemic (HI) neonatal brain injury model. The Rice-Vannucci method was used in 10-day-old rat pups by performing unilateral carotid artery ligation followed by 2 h of hypoxia (8% O₂ at 37°C). Capsaicin was administered intraperitoneally (0.2 mg/kg or 2.0 mg/kg) at 3 h pre-HI or 1 h post-HI. Post assessment included measurement of infarction volume at 24 and 72 h in addition to an assessment of the vascular dynamics of the middle cerebral artery (MCA) at 6 h post-HI. The results indicated that pre-treatment with capsaicin reduced infarction volume significantly with either low-dose or high-dose treatment. Pre-treatment also improved myogenic tone and decreased apoptotic changes in the distal MCA. We concluded that capsaicin pre-treatment may provide neurovascular protection against neonatal HI.

Original language	American English
Title of host publication	Intracerebral Hemorrhage Research
Subtitle of host publication	From Bench to Bedside
Publisher	Springer-Verlag Wien
Pages	225-230
Number of pages	6
Volume	111
Edition	111
ISBN (Print)	9783709106921
DOIs	https://doi.org/10.1007/978-3-7091-0693-8_38 https://doi.org/10.1007/978-3-7091-0693-8_38
State	Published - Jan 1 2011

Publication series

Name	Acta Neurochirurgica, Supplementum
Number	111
ISSN (Print)	0065-1419
ISSN (Electronic)	0001-6268

ASJC Scopus Subject Areas

Surgery
Clinical Neurology

Keywords

Capsaicin
Neonatal hypoxia ischemia
Transient receptor potential vanilloid 1 (TRPV1)

Disciplines

Medicine and Health Sciences
Anesthesiology

Access to Document

10.1007/978-3-7091-0693-8_38
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Khatibi, N. H., Jadhav, V., Charles, S., Chiu, J., Buchholz, J., Tang, J., & Zhang, J. H. (2011). Capsaicin Pre-treatment Provides Neurovascular Protection Against Neonatal Hypoxic-Ischemic Brain Injury in Rats. In Intracerebral Hemorrhage Research: From Bench to Bedside (111 ed., Vol. 111, pp. 225-230). (Acta Neurochirurgica, Supplementum; No. 111). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-0693-8_38, https://doi.org/10.1007/978-3-7091-0693-8_38

Capsaicin Pre-treatment Provides Neurovascular Protection Against Neonatal Hypoxic-Ischemic Brain Injury in Rats. / Khatibi, Nikan H.; Jadhav, Vikram; Charles, Shelton et al.
Intracerebral Hemorrhage Research: From Bench to Bedside. Vol. 111 111. ed. Springer-Verlag Wien, 2011. p. 225-230 (Acta Neurochirurgica, Supplementum; No. 111).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Khatibi, NH, Jadhav, V, Charles, S, Chiu, J, Buchholz, J , Tang, J & Zhang, JH 2011, Capsaicin Pre-treatment Provides Neurovascular Protection Against Neonatal Hypoxic-Ischemic Brain Injury in Rats. in Intracerebral Hemorrhage Research: From Bench to Bedside. 111 edn, vol. 111, Acta Neurochirurgica, Supplementum, no. 111, Springer-Verlag Wien, pp. 225-230. https://doi.org/10.1007/978-3-7091-0693-8_38, https://doi.org/10.1007/978-3-7091-0693-8_38

Khatibi NH, Jadhav V, Charles S, Chiu J, Buchholz J , Tang J et al. Capsaicin Pre-treatment Provides Neurovascular Protection Against Neonatal Hypoxic-Ischemic Brain Injury in Rats. In Intracerebral Hemorrhage Research: From Bench to Bedside. 111 ed. Vol. 111. Springer-Verlag Wien. 2011. p. 225-230. (Acta Neurochirurgica, Supplementum; 111). doi: 10.1007/978-3-7091-0693-8_38, 10.1007/978-3-7091-0693-8_38

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abstract = "Capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has recently been shown to provide neuroprotection against brain injury in experimental adult models of cerebral ischemia. Accordingly, in this study, we investigated the way in which capsaicin-mediated TRPV1 modulation could attenuate damage in an experimental hypoxic-ischemic (HI) neonatal brain injury model. The Rice-Vannucci method was used in 10-day-old rat pups by performing unilateral carotid artery ligation followed by 2 h of hypoxia (8% O2 at 37°C). Capsaicin was administered intraperitoneally (0.2 mg/kg or 2.0 mg/kg) at 3 h pre-HI or 1 h post-HI. Post assessment included measurement of infarction volume at 24 and 72 h in addition to an assessment of the vascular dynamics of the middle cerebral artery (MCA) at 6 h post-HI. The results indicated that pre-treatment with capsaicin reduced infarction volume significantly with either low-dose or high-dose treatment. Pre-treatment also improved myogenic tone and decreased apoptotic changes in the distal MCA. We concluded that capsaicin pre-treatment may provide neurovascular protection against neonatal HI.",

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N2 - Capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has recently been shown to provide neuroprotection against brain injury in experimental adult models of cerebral ischemia. Accordingly, in this study, we investigated the way in which capsaicin-mediated TRPV1 modulation could attenuate damage in an experimental hypoxic-ischemic (HI) neonatal brain injury model. The Rice-Vannucci method was used in 10-day-old rat pups by performing unilateral carotid artery ligation followed by 2 h of hypoxia (8% O2 at 37°C). Capsaicin was administered intraperitoneally (0.2 mg/kg or 2.0 mg/kg) at 3 h pre-HI or 1 h post-HI. Post assessment included measurement of infarction volume at 24 and 72 h in addition to an assessment of the vascular dynamics of the middle cerebral artery (MCA) at 6 h post-HI. The results indicated that pre-treatment with capsaicin reduced infarction volume significantly with either low-dose or high-dose treatment. Pre-treatment also improved myogenic tone and decreased apoptotic changes in the distal MCA. We concluded that capsaicin pre-treatment may provide neurovascular protection against neonatal HI.

AB - Capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has recently been shown to provide neuroprotection against brain injury in experimental adult models of cerebral ischemia. Accordingly, in this study, we investigated the way in which capsaicin-mediated TRPV1 modulation could attenuate damage in an experimental hypoxic-ischemic (HI) neonatal brain injury model. The Rice-Vannucci method was used in 10-day-old rat pups by performing unilateral carotid artery ligation followed by 2 h of hypoxia (8% O2 at 37°C). Capsaicin was administered intraperitoneally (0.2 mg/kg or 2.0 mg/kg) at 3 h pre-HI or 1 h post-HI. Post assessment included measurement of infarction volume at 24 and 72 h in addition to an assessment of the vascular dynamics of the middle cerebral artery (MCA) at 6 h post-HI. The results indicated that pre-treatment with capsaicin reduced infarction volume significantly with either low-dose or high-dose treatment. Pre-treatment also improved myogenic tone and decreased apoptotic changes in the distal MCA. We concluded that capsaicin pre-treatment may provide neurovascular protection against neonatal HI.

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Capsaicin Pre-treatment Provides Neurovascular Protection Against Neonatal Hypoxic-Ischemic Brain Injury in Rats

Abstract

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ASJC Scopus Subject Areas

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