Cannabinoid Receptor Type 2 Agonist Attenuates Acute Neurogenic Pulmonary Edema by Preventing Neutrophil Migration after Subarachnoid Hemorrhage in Rats

Mutsumi Fujii, Prativa Sherchan, Yoshiteru Soejima, Desislava Doycheva, Diana Zhao, John H. Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Clinical- pathological analysis of fatal SAH showed that 70–90 % of deaths were associated with NPE [ 12 ,17 ], whereas only 31 % had clinically diagnosed NPE [ 17 ]. However, NPE after SAH continues to be a prevalent clinical problem with few effi cient pharmacological treatment options. Some studies have indicated that cannabinoid receptor type 2 (CB2R) activation plays important roles in preventing septic lung injury by attenuating neutrophil recruitment [ 16 ]. Since the infl ux of neutrophils can aggravate lung damage, inhibiting infi ltration of neutrophils by CB2R agonist may reduce NPE after SAH.

Original languageAmerican English
Title of host publicationBrain Edema XVI
PublisherSpringer-Verlag Wien
Pages135-139
Number of pages5
Volume121
DOIs
StatePublished - 2016

Publication series

NameActa Neurochirurgica, Supplementum
Volume121
ISSN (Print)0065-1419
ISSN (Electronic)2197-8395

ASJC Scopus Subject Areas

  • Surgery
  • Clinical Neurology

Disciplines

  • Pharmacology
  • Pathology
  • Medicine and Health Sciences

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