TY - JOUR
T1 - Adult Orbital Xanthogranulomatous Disease
T2 - A Review with Emphasis on Etiology, Systemic Associations, Diagnostic Tools, and Treatment
AU - Kerstetter, Justin
AU - Wang, Jun
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015
Y1 - 2015
N2 - Adult orbital xanthogranulomatous diseases are rare entities and encompass a group of disorders with varying manifestations that are poorly understood. Taken as a group, there are non-Langerhans histiocytic disorders (type II) that are diagnosed histologically by the presence of foamy histiocytes, Touton giant cells, and varying degrees of fibrosis. Based on the accompanying systemic associations, there are 4 main categories of adult xanthogranulomatous disease: adult-onset xanthogranuloma, adult-onset asthma and periocular xanthogranuloma, necrobiotic xanthogranuloma, and Erdheim-Chester disease. Herein, we discuss the etiopathogenesis, systemic associations, methods of diagnosis, and treatment options for these disorders.
AB - Adult orbital xanthogranulomatous diseases are rare entities and encompass a group of disorders with varying manifestations that are poorly understood. Taken as a group, there are non-Langerhans histiocytic disorders (type II) that are diagnosed histologically by the presence of foamy histiocytes, Touton giant cells, and varying degrees of fibrosis. Based on the accompanying systemic associations, there are 4 main categories of adult xanthogranulomatous disease: adult-onset xanthogranuloma, adult-onset asthma and periocular xanthogranuloma, necrobiotic xanthogranuloma, and Erdheim-Chester disease. Herein, we discuss the etiopathogenesis, systemic associations, methods of diagnosis, and treatment options for these disorders.
KW - Adult onset asthma with periorbital xanthogranuloma
KW - Adult orbital xanthogranulomatous disease
KW - Erdheim-Chester disease
KW - Necrobiotic xanthogranuloma
KW - Orbital inflammation
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U2 - 10.1016/j.det.2015.03.010
DO - 10.1016/j.det.2015.03.010
M3 - Review article
C2 - 26143425
SN - 0733-8635
VL - 33
SP - 457
EP - 463
JO - Dermatologic Clinics
JF - Dermatologic Clinics
IS - 3
ER -