Research output per year
Research output per year
Personal profile
About
Cell Plasticity: the connection between normal and cancer stem cells
Cell plasticity is defined as the cell capability to change its phenotype in response to microenvironmental signals. Stem cells are a prototype of cells with high plasticity because their physiological role in generating a variety of cell types both during development as in tissue regeneration.
Interestingly, most human tumors contain a minor subpopulation of malignant cells with stem cells characterisitcs and high plasticity as well. Those cells are known as cancer stem cells (CSC) or tumor initiating cells because their strong capability to originate and support tumors.
My lab is exploring the interconnection between normal and cancer stem cells. We are using human induced pluripotent stem cells (iPSC) and cancer stem cells to explore the level of plasticity existing at those cells types. By manipulating in vitro the cell microenvironment we are studying a potential connection between iPSC and CSC.
Related documents
Education/Academic qualification
PhD, Pontificia Universidad Católica de Chile
… → 1994
MS, Universidad de Concepción
… → 1982
Disciplines
- Medicine and Health Sciences
-
Newly identified breast luminal progenitor and gestational stem cell populations likely give rise to HER2-overexpressing and basal-like breast cancers
McMullen, J. R. W. & Soto, U., Dec 2022, In: Discover Oncology. 13, 1, 38.Research output: Contribution to journal › Article › peer-review
Open Access -
The ledgf/p75 integrase binding domain interactome contributes to the survival, clonogenicity, and tumorsphere formation of docetaxel-resistant prostate cancer cells
Ortiz-Hernandez, G. L., Sanchez-Hernandez, E. S., Ochoa, P. T., Elix, C. C., Alkashgari, H. R., McMullen, J. R. W., Soto, U., Martinez, S. R., Diaz Osterman, C. J., Mahler, M., Roy, S. & Casiano, C. A., Oct 2021, In: Cells. 10, 10, 2723.Research output: Contribution to journal › Article › peer-review
Open Access -
AhR ligand aminoflavone suppresses α6-integrin–Src–Akt signaling to attenuate tamoxifen resistance in breast cancer cells
Campbell, P. S., Mavingire, N., Khan, S., Rowland, L. K., Wooten, J. V., Opoku-Agyeman, A., Guevara, A., Soto, U., Cavalli, F., Loaiza-Pérez, A. I., Nagaraj, G., Denham, L. J., Adeoye, O., Jenkins, B. D., Davis, M. B., Schiff, R. & Brantley, E. J., Jan 2018, In: Journal of Cellular Physiology. 234, 1, p. 108-121 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
RNA sequencing reveals upregulation of a transcriptomic program associated with stemness in metastatic prostate cancer cells selected for taxane resistance
Ross, C. K. C. D., Martinez, S. R., Woods-Burnham, L., Durán, A. M., Roy, S., Basu, A., Ramirez, J. A., Ortiz-Hernández, G. L., Ríos-Colón, L., Chirshev, E., Sanchez-Hernandez, E. S., Soto, U., Greco, C., Boucheix, C., Chen, X., Unternaehrer, J., Wang, C. & Casiano, C. A., Jul 1 2018, In: Oncotarget. 9, 54, p. 30363-30384 22 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Abstract 4177: Anticancer agent Aminoflavone restores the expression of tumor suppressor miRNA 26a and inhibits putative stemness biomarker α6-integrin in Tamoxifen resistant cells
Campbell, P., Rowland, L., Opoku-Agyeman, A., Mavingire, N., Soto, U., Nagaraj, G., Zhang, Y., Chen, S., Wang, C., Brantley, E. & Soto-Wegner, U., Jul 1 2017, In: Cancer Research. 77Research output: Contribution to journal › Article › peer-review