The Lawrence D. Longo, MD Center for Perinatal Biology

Research output

Research output per year 1990 2000 2009 2014 2017 2019 2024

• 314 Article
• 46 Review article
• 7 Chapter
• 3 Editorial
• 6 More
  • 2 Book
  • 2 Foreword/postscript
  • 1 Letter
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2024

  Prenatal Nicotine Exposure Raises Male Blood Pressure via FTO-Mediated NOX2/ROS Signaling

  Liu, B., Xia, L., Li, Y., Jiang, S., Yu, W., Zhang, L., Shao, X. M., Xu, Z. & Xiao, D., Feb 1 2024, In: Hypertension. 81, 2, p. 240-251 12 p.

  Research output: Contribution to journal › Article › peer-review

• STZ-induced gestational diabetes exposure alters PTEN/AKT/mTOR-mediated autophagy signaling pathway leading to increase the risk of neonatal hypoxic-ischemic encephalopathy

  Gong, L., Jiang, S., Tian, J., Li, Y., Yu, W., Zhang, L. & Xiao, D., Jan 2024, In: Reproductive Toxicology. 123, 108494.

  Research output: Contribution to journal › Article › peer-review
• 2023

  3D doppler ultrasound imaging of cerebral blood flow for assessment of neonatal hypoxic-ischemic brain injury in mice

  Shen, G., Sanchez, K., Hu, S., Zhao, Z., Zhang, L. & Ma, Q., May 2023, In: PLoS ONE. 18, 5 May, e0285434.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Fetal hypoxia results in sex- and cell type-specific alterations in neonatal transcription in rat oligodendrocyte precursor cells, microglia, neurons, and oligodendrocytes

  Kremsky, I., Ma, Q., Li, B., Dasgupta, C., Chen, X., Ali, S., Angeloni, S., Wang, C. & Zhang, L., Dec 2023, In: Cell and Bioscience. 13, 1, 58.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Glucocorticoid Receptor and β-Catenin Interact in Prostate Cancer Cells and Their Co-Inhibition Attenuates Tumorsphere Formation, Stemness, and Docetaxel Resistance

  Martinez, S. R., Elix, C. C., Ochoa, P. T., Sanchez-Hernandez, E. S., Alkashgari, H. R., Ortiz-Hernandez, G. L., Zhang, L. & Casiano, C. A., Apr 2023, In: International Journal of Molecular Sciences. 24, 8, 7130.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Improved Workflow for Analysis of Vascular Myocyte Time-Series and Line-Scan Ca²⁺ Imaging Datasets

  Boskind, M., Nelapudi, N., Williamson, G., Mendez, B., Juarez, R., Zhang, L., Blood, A. B., Wilson, C. G., Puglisi, J. L. & Wilson, S. M., Jun 2023, In: International Journal of Molecular Sciences. 24, 11, 9729.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• MicroRNA-210 Downregulates TET2 (Ten-Eleven Translocation Methylcytosine Dioxygenase 2) and Contributes to Neuroinflammation in Ischemic Stroke of Adult Mice

  Li, Y., Song, R., Shen, G., Huang, L., Xiao, D. L., Ma, Q. & Zhang, L., Mar 1 2023, In: Stroke. 54, 3, p. 857-867 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• TET2 confers a mechanistic link of microRNA-210 and mtROS in hypoxia-suppressed spontaneous transient outward currents in uterine arteries of pregnant sheep

  Hu, X. Q., Song, R., Dasgupta, C., Blood, A. B. & Zhang, L., Apr 15 2023, In: Journal of Physiology. 601, 8, p. 1501-1514 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2022

  Chronic High-Altitude Hypoxia Alters Iron and Nitric Oxide Homeostasis in Fetal and Maternal Sheep Blood and Aorta

  Liu, T., Zhang, M., Mourkus, A., Schroeder, H., Zhang, L., Power, G. G. & Blood, A. B., Sep 2022, In: Antioxidants. 11, 9, 1821.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Long-Term Hypoxia Negatively Influences Ca²⁺ Signaling in Basilar Arterial Myocytes of Fetal and Adult Sheep

  Reid, C., Romero, M., Chang, S. B., Osman, N., Puglisi, J. L., Wilson, C. G., Blood, A. B., Zhang, L. & Wilson, S. M., Jan 18 2022, In: Frontiers in Physiology. 12, 760176.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction

  Song, R., Dasgupta, C., Mulder, C. & Zhang, L., Apr 12 2022, In: Circulation. 145, 15, p. 1140-1153 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• MicroRNA-210-mediated mtROS confer hypoxia-induced suppression of STOCs in ovine uterine arteries

  Hu, X. Q., Song, R., Dasgupta, C., Romero, M., Juarez, R., Hanson, J., Blood, A. B., Wilson, S. M. & Zhang, L., Oct 2022, In: British Journal of Pharmacology. 179, 19, p. 4640-4654 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The Regulatory Role of H19/miR-181a/ATG5 Signaling in Perinatal Nicotine Exposure-Induced Development of Neonatal Brain Hypoxic-Ischemic Sensitive Phenotype

  Li, Y., Zhang, Y., Walayat, A., Fu, Y., Liu, B., Zhang, L. & Xiao, D., Jul 1 2022, In: International Journal of Molecular Sciences. 23, 13, 6885.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2021

  C-type natriuretic peptide ameliorates vascular injury and improves neurological outcomes in neonatal hypoxic-ischemic brain injury in mice

  Shen, G., Hu, S., Zhao, Z., Zhang, L. & Ma, Q., Aug 2 2021, In: International Journal of Molecular Sciences. 22, 16, 8966.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive phenotype via altering DNA methylation patterns and autophagy signaling pathway

  Walayat, A., Li, Y., Zhang, Y., Fu, Y., Liu, B., Shao, X. M., Zhang, L. & Xiao, D., Nov 1 2021, In: American journal of physiology. Regulatory, integrative and comparative physiology. 321, 5, p. R791-R801

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Gestational long-term hypoxia induces metabolomic reprogramming and phenotypic transformations in fetal sheep pulmonary arteries

  Leslie, E., Lopez, V., Anti, N. A. O., Alvarez, R., Kafeero, I., Welsh, D. G., Romero, M., Kaushal, S., Johnson, C. M., Bosviel, R., Blaženović, I., Song, R., Brito, A., la Frano, M. R., Zhang, L., Newman, J. W., Fiehn, O. & Wilson, S. M., May 2021, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 320, 5, p. L770-L784

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Inhibition of DNA methylation in newborns reprograms ischemia-sensitive biomarkers resulting in development of a heart ischemia-sensitive phenotype late in life

  Zhang, Y., Yang, M., Li, Y., Liu, B., Zhang, L. & Xiao, D., Oct 2021, In: Reproductive Toxicology. 105, p. 198-210 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• MicroRNA-210 downregulates TET2 and contributes to inflammatory response in neonatal hypoxic-ischemic brain injury

  Ma, Q., Dasgupta, C., Shen, G., Li, Y. & Zhang, L., Dec 2021, In: Journal of Neuroinflammation. 18, 1, 6.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• MicroRNA-210 Mediates Hypoxia-Induced Repression of Spontaneous Transient Outward Currents in Sheep Uterine Arteries during Gestation

  Hu, X. Q., Dasgupta, C., Song, R., Romero, M., Wilson, S. M. & Zhang, L., Apr 1 2021, In: Hypertension. 77, 4, p. 1412-1427 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Ryanodine receptor subtypes regulate Ca²⁺sparks/spontaneous transient outward currents and myogenic tone of uterine arteries in pregnancy

  Song, R., Hu, X. Q., Romero, M., Holguin, M. A., Kagabo, W., Xiao, D., Wilson, S. M. & Zhang, L., Mar 1 2021, In: Cardiovascular Research. 117, 3, p. 792-804 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2020

  Antenatal Hypoxia Accelerates the Onset of Alzheimer’s Disease Pathology in 5xFAD Mouse Model

  Shen, G., Hu, S., Zhao, Z., Zhang, L. & Ma, Q., Aug 21 2020, In: Frontiers in Aging Neuroscience. 12, 251.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases

  Bonnet, S., Boucherat, O., Paulin, R., Wu, D., Hindmarch, C. C. T., Archer, S. L., Song, R., Moore Iv, J. B., Provencher, S., Zhang, L. & Uchida, S., 2020, In: American Journal of Physiology - Cell Physiology. 318, 1, p. C1-C28

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Early detection of coronary artery disease by micro-RNA analysis in asymptomatic patients stratified by coronary CT angiography

  Patterson, A. J., Song, M. A., Choe, D., Xiao, D., Foster, G. & Zhang, L., Nov 2020, In: Diagnostics. 10, 11, 875.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Fetal hypoxia impacts on proliferation and differentiation of sca-1⁺ cardiac progenitor cells and maturation of cardiomyocytes: A role of microRNA-210

  Meng, X., Zhang, P. & Zhang, L., Mar 2020, In: Genes. 11, 3, 328.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Gestational High‐Altitude Hypoxia and Metabolomic Reprogramming in Pulmonary Arteries from Fetal Sheep

  Leslie, E., Jones, B., Alvarez, R., Dasgupta, C., Fiehn, O., Bosviel, R., Newman, J. W., La Frano, M., Zhang, L. & Wilson, S. M., Apr 1 2020, In: The FASEB Journal. 34

  Research output: Contribution to journal › Article › peer-review

• Gestational Hypoxia Inhibits Pregnancy-Induced Upregulation of Ca²⁺Sparks and Spontaneous Transient Outward Currents in Uterine Arteries Via Heightened Endoplasmic Reticulum/Oxidative Stress

  Hu, X. Q., Song, R., Romero, M., Dasgupta, C., Min, J., Hatcher, D., Xiao, D., Blood, A., Wilson, S. M. & Zhang, L., Sep 1 2020, In: Hypertension. 76, 3, p. 930-942 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• High Altitude Hypoxia Induces Cellular Immaturity of Pulmonary Arteries in the Fetal Lamb: Assessment of Protein Biomarkers

  Jones, B., Leslie, E., Alvarez, R., Dasgupta, C., Zhang, L. & Wilson, S. M., Apr 1 2020, In: The FASEB Journal. 34

  Research output: Contribution to journal › Article › peer-review

• Inhibition of autophagy signaling via 3-methyladenine rescued nicotine-mediated cardiac pathological effects and heart dysfunctions

  Zhang, P., Li, Y., Fu, Y., Huang, L., Liu, B., Zhang, L., Shao, X. M. & Xiao, D., 2020, In: International Journal of Biological Sciences. 16, 8, p. 1349-1362 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy

  Li, B., Dasgupta, C., Huang, L., Meng, X. & Zhang, L., Sep 1 2020, In: Cellular & molecular immunology. 17, 9, p. 976-991 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Prenatal High-Salt Diet–Induced Metabolic Disorders via Decreasing Peroxisome Proliferator–Activated Receptor Gamma Coactivator 1α in Adult Male Rat Offspring

  Liu, Y., Yang, C., Feng, X., Qi, L., Guo, J., Zhu, D., Thai, P. N., Zhang, Y., Zhang, P., Sun, M., Lv, J., Zhang, L., Xu, Z. & Lu, X., Jul 1 2020, In: Molecular Nutrition and Food Research. 64, 14, 2000196.

  Research output: Contribution to journal › Article › peer-review

• Reprogramming of miR-181a/DNA methylation patterns contribute to the maternal nicotine exposure-induced fetal programming of cardiac ischemia-sensitive phenotype in postnatal life

  Jian, J., Zhang, P., Li, Y., Liu, B., Zhang, Y., Zhang, L., Shao, X. M., Zhuang, J. & Xiao, D., 2020, In: Theranostics. 10, 25, p. 11820-11836 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• TRPML channel activation partially rescues Ca 2+ spark activity in sheep fetal pulmonary arterial myocytes following intrauterine long‐term hypoxia

  Ang, D., Romero, M. M., Puglisi, J. L., Zhang, L. & Wilson, S. M., Apr 1 2020, In: The FASEB Journal. 34

  Research output: Contribution to journal › Article › peer-review
• 2019

  Abstract 2620: Global epigenetic regulation of gene expression and tumor suppression in T-cell leukemia by Ikaros

  Ding, Y., Zhang, B., Payne, J. L., Payne, K. J., Song, C., Gowda, C., Iyer, S., Dhanyamraju, P. K., Desai, D., Huang, S., Yue, F. & Dovat, S., Jul 1 2019, In: Cancer Research. 79

  Research output: Contribution to journal › Article › peer-review

• Abstract LB-260: Role of the glucocorticoid receptor/beta-catenin interaction in prostate cancer stem cell survival and chemoresistance

  Martinez, S. R., Osterman, C. J. D., Chen, X. S., Wang, C., Zhang, L. & Casiano, C. A., Jul 1 2019, In: Cancer Research. 79

  Research output: Contribution to journal › Article › peer-review

• Antenatal hypoxia and programming of glucocorticoid receptor expression in the adult rat heart

  Lv, J., Ma, Q., Dasgupta, C., Xu, Z. & Zhang, L., 2019, In: Frontiers in Physiology. 10, APR, 323.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• CK2 Inhibitor CX4945 Shows Strong In Vivo Anti Leukemia Effect in AML Via Augmented Ikaros-Mediated Regulation of Global Epigenetic Landscape

  Gowda, C., Song, C., Steffens, S., Ding, Y., Zhang, B., Yue, F., Iyer, S., Dhanyamraju, P. K., Payne, J., Payne, J., Reed, M., Payne, K. J. & Dovat, S., Nov 13 2019, In: Blood. 134

  Research output: Contribution to journal › Article › peer-review

• Effect of Oxidative Stress on the Estrogen-NOS-NO-KCa Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications

  Hu, X-Q., Song, R. & Zhang, L., Feb 10 2019, In: Oxidative Medicine and Cellular Longevity. 2019

  Research output: Contribution to journal › Article › peer-review

• Epigenetic down-regulation of BK _Ca channel by miR-181a contributes to the fetal and neonatal nicotine-mediated exaggerated coronary vascular tone in adult life

  Liu, B., Hu, X., Li, Y., Ke, J., Dasgupta, C., Huang, X., Walayat, A., Zhang, L. & Xiao, D., Apr 15 2019, In: International Journal of Cardiology. 281, p. 82-89 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Epigenetic down-regulation of BKCa channel by miR-181a contributes to the fetal and neonatal nicotine-mediated exaggerated coronary vascular tone in adult life.

  Liu, B., Hu, X., Li, Y., Ke, J., Dasgupta, C., Huang, X., Walayat, A., Zhang, L. & Xiao, D., Apr 15 2019, In: International Journal of Cardiology. 281

  Research output: Contribution to journal › Article › peer-review

• Epigenetic down-regulation of sirt 1 via DNA methylation and oxidative stress signaling contributes to the gestational diabetes mellitus-induced fetal programming of heart ischemia-sensitive phenotype in late life

  Chen, Z., Gong, L., Zhang, P., Li, Y., Liu, B., Zhang, L., Zhuang, J. & Xiao, D., 2019, In: International Journal of Biological Sciences. 15, 6, p. 1240-1251 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Foetal hypoxia impacts methylome and transcriptome in developmental programming of heart disease

  Huang, L., Chen, X., Dasgupta, C., Chen, W., Song, R., Wang, C. & Zhang, L., Jul 1 2019, In: Cardiovascular Research. 115, 8, p. 1306-1319 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Long-term exposure to high altitude hypoxia during pregnancy increases fetal heart susceptibility to ischemia/reperfusion injury and cardiac dysfunction

  Zhang, P., Ke, J., Li, Y., Huang, L., Chen, Z., Huang, X., Zhang, L. & Xiao, D., Jan 1 2019, In: International Journal of Cardiology. 274, p. 7-15 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Long-term high-altitude hypoxia and alpha adrenoceptor-dependent pulmonary arterial contractions in fetal and adult sheep

  Moretta, D., Papamatheakis, D. G., Morris, D. P., Giri, P. C., Blood, Q., Murray, S., Ramzy, M., Romero, M., Vemulakonda, S., Lauw, S., Longo, L. D., Zhang, L. & Wilson, S. M., 2019, In: Frontiers in Physiology. 10, AUG, 1032.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Maternal High-Sucrose Diet Accelerates Vascular Stiffness in Aged Offspring via Suppressing Ca_v1.2 and Contractile Phenotype of Vascular Smooth Muscle Cells

  Feng, X., Li, X., Yang, C., Ren, Q., Zhang, W., Li, N., Zhang, M., Zhang, B., Zhang, L., Zhou, X. & Xu, Z., Jul 2019, In: Molecular Nutrition and Food Research. 63, 14, 1900022.

  Research output: Contribution to journal › Article › peer-review

• MicroRNA-210 Downregulates ISCU and Induces Mitochondrial Dysfunction and Neuronal Death in Neonatal Hypoxic-Ischemic Brain Injury

  Ma, Q., Dasgupta, C., Li, Y., Huang, L. & Zhang, L., Aug 15 2019, In: Molecular Neurobiology. 56, 8, p. 5608-5625 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• MicroRNAs in brain development and cerebrovascular pathophysiology

  Ma, Q., Zhang, L. & Pearce, W. J., 2019, In: American Journal of Physiology - Cell Physiology. 317, 1, p. C3-C19

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Mitochondrial mirna in cardiovascular function and disease

  Song, R., Hu, X. Q. & Zhang, L., Dec 2019, In: Cells. 8, 12, 1475.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Multi-omics integration reveals short and long-term effects of gestational hypoxia on the heart development

  Gao, Y., Dasgupta, C., Huang, L., Song, R., Zhang, Z. & Zhang, L., Dec 2019, In: Cells. 8, 12, 1608.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Perinatal nicotine exposure alters Akt/GSK-3β/mTOR/autophagy signaling, leading to development of hypoxic-ischemic-sensitive phenotype in rat neonatal brain

  Li, Y., Song, A. M., Fu, Y., Walayat, A., Yang, M., Jian, J., Liu, B., Xia, L., Zhang, L. & Xiao, D., 2019, In: American journal of physiology. Regulatory, integrative and comparative physiology. 317, 6, p. R803-R813

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Pregnancy increases Ca²⁺ sparks/spontaneous transient outward currents and reduces uterine arterial myogenic tone

  Hu, X. Q., Song, R., Romero, M., Dasgupta, C., Huang, X., Holguin, M. A., Williams, V. S., Xiao, D., Wilson, S. M. & Zhang, L., Mar 1 2019, In: Hypertension. 73, 3, p. 691-702 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access